tobramycin (Q1758380)

tobramycin metabolic process

Tobramycin (English)

23 September 2015

participant

1 reference

Gene Ontology release 2019-11-16

tobramycin catabolic process

reactant

1 reference

Gene Ontology release 2019-11-16

tobramycin biosynthetic process

product

1 reference

Gene Ontology release 2019-11-16

chemical structure

Tobramycin.svg
490 × 190; 4 KB

0 references

mass

467.259 dalton

1 reference

tobramycin (English)

17 November 2016

C₁₈H₃₇N₅O₉

1 reference

tobramycin (English)

17 November 2016

C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N

1 reference

tobramycin (English)

17 November 2016

C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N

1 reference

European Medicines Agency product number

tobramycin (English)

17 November 2016

1 reference

EMEA/H/C/002155

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002155/human_med_001401.jsp

European Medicines Agency product number

22 March 2017

Vantobra

1 reference

EMEA/H/C/002633

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002633/human_med_001773.jsp

22 March 2017

1 reference

14 February 2018

1 reference

14 February 2018

1 reference

14 February 2018

1 reference

14 February 2018

World Health Organisation international non-proprietary name

tobramycin (English)

2 references

Streptoalloteichus hindustanus

Tobramycin (English)

9 October 2015

Recommended INN: List 15

publication date

1975

found in taxon

1 reference

Biosynthesis of 2-deoxystreptamine-containing antibiotics in Streptoalloteichus hindustanus JCM 3268: characterization of 2-deoxy-scyllo-inosose synthase.

Streptomyces cremeus

9 references

Isolation and characterization of the tobramycin biosynthetic gene cluster from Streptomyces tenebrarius

An approach for cloning biosynthetic genes of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius

Cloning and analysis of a gene (SMS13) encoding sannamycin B-glycyltransferase from Streptomyces sannanensis and its distribution among actinomycetes.

Characterization of L-glutamine:2-deoxy-scyllo-inosose aminotransferase (tbmB) from Streptomyces tenebrarius

Analysis of a ribosomal RNA methylase gene from Streptomyces tenebrarius which confers resistance to gentamicin.

Construction of kanamycin B overproducing strain by genetic engineering of Streptomyces tenebrarius.

Involvement of 16S ribosomal RNA in resistance of the aminoglycoside-producers Streptomyces tenjimariensis, Streptomyces tenebrarius and Micromonospora purpurea

Identification and functional analysis of dTDP-glucose-4,6-dehydratase gene and its linked gene cluster in an aminoglycoside antibiotics producer of Streptomyces tenebrarius H6.

Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption

Aspergillus fumigatus

1 reference

Helvolic Acid Derivatives with Antibacterial Activities against Streptococcus agalactiae from the Marine-Derived Fungus Aspergillus fumigatus HNMF0047

Serratia plymuthica

1 reference

Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2.

medical condition treated

upper respiratory tract infection

1 reference

13 December 2016

urinary tract infection

1 reference

gram-negative bacterial infection

13 December 2016

1 reference

13 December 2016

Pseudomonas infection

1 reference

13 December 2016

staphylococcal infection

2 references

13 December 2016

https://www.ncbi.nlm.nih.gov/pubmed/789045

conjunctivitis

1 reference

bacterial infectious disease

2 October 2018

1 reference

2 October 2018

cystic fibrosis

1 reference

2 October 2018

pneumonia

1 reference

2 October 2018

bronchiectasis

1 reference

Food and Drug Administration

2 October 2018

12 February 2014

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/VZ8RRZ51VK

significant drug interaction

foscarnet

1 reference

A reference set of clinically relevant adverse drug-drug interactions

vancomycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cyclosporine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

carboplatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bumetanide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

vancomycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

furosemide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

furosemide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

carboplatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cisplatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cisplatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bumetanide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

rocuronium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

rocuronium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

rocuronium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

mivacurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

mivacurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

mivacurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atracurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atracurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atracurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Cisatracurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Cisatracurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Cisatracurium

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cyclosporine

kidney failure

1 reference

A reference set of clinically relevant adverse drug-drug interactions

succinylcholine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

succinylcholine

apnea

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cisplatin

kidney failure

1 reference

A reference set of clinically relevant adverse drug-drug interactions

legal status (medicine)

boxed warning

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

manufacturer

Pfizer

1 reference

https://www.pfizer.com/products/product-list

protein synthesis inhibitor

1 reference

5 March 2018

1 reference

Medical Subject Headings

MeSH descriptor ID

D014031

‎WHO Aware Classification

15 March 2018

watch

1 reference

2023 ‎AWaRe classification‎

Commons category

Tobramycin

0 references

Identifiers

InChI

InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1

1 reference

NLVFBUXFDBBNBW-PBSUHMDJSA-N

tobramycin (English)

17 November 2016

2 references

tobramycin (English)

17 November 2016

ChEBI release 2020-09-01

CAS Registry Number

32986-56-4

2 references

NLVFBUXFDBBNBW-PBSUHMDJSA-N

tobramycin (English)

17 November 2016

10 April 2021

https://commonchemistry.cas.org/detail?cas_rn=32986-56-4

1 reference

Tobramycin (English)

17 November 2016

1 reference

tobramycin (English)

17 November 2016

Reaxys registry number

1357507

1 reference

tobramycin (English)

19 October 2016

mapping relation type

1 reference

TOBRAMYCIN (English)

17 November 2016

1 reference

splash10-03di-0911100000-b28142c63090941c9e87

TOBRAMYCIN (English)

17 November 2016

1 reference

0 references

HSDB ID

3259

1 reference

Hazardous Substances Data Bank

28 October 2019

Tobramycin (English)

10 May 2021

1 reference

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

0 references

251-322-5

1 reference

tobramycin (English)

ECHA Substance Infocard ID

17 November 2016

100.046.642

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

Tobramycin (English)

CAS no.: 32986-56-4 (English)

1 reference

Tobramycin (English)

23 September 2015

1 reference

World Health Organisation international non-proprietary name numeric ID

Tobramycin (English)

publication date

23 September 2015

2990

1 reference

https://mednet-communities.net/inn/db/ViewINN.aspx?i=2990

Guide to Pharmacology Ligand ID

10930

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

5 February 2021

Tobramycin

1 reference

Medical Subject Headings

14 March 2018

D09.408.051.476.600.800

0 references

RxNorm ID

10627

1 reference

tobramycin (English)

17 November 2016

1 reference

Tobramycin (English)

Human Metabolome Database ID

17 November 2016

HMDB0014822

1 reference

based on heuristic

inferred from InChIKey

1 reference

tobramycin (English)

MedlinePlus drug identifier

17 November 2016

Natural Product Atlas ID

NPA024722

1 reference

based on heuristic

inferred from InChIKey

a681003

route of administration

intravenous injection

intramuscular injection

0 references

a682660

route of administration

0 references

1 reference

tobramycin (English)

17 November 2016

0 references

1 reference

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

tobramycin (English)

19 October 2016

0 references

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

1M4D (English)

19 October 2016

1 reference

3SG8 (English)

19 October 2016

1 reference

5CFS (English)

19 October 2016

1 reference

4LFC (English)

19 October 2016

1 reference

4EBK (English)

19 October 2016

1 reference

4EVY (English)

19 October 2016

1 reference

1LC4 (English)

19 October 2016

1 reference

3VET (English)

19 October 2016

1 reference

4XJE (English)

19 October 2016

1 reference

4JD6 (English)

19 October 2016

1 reference

tobramycin (English)

17 November 2016

0 references

WordNet 3.1 Synset ID

04450722-n

1 reference