Interleukin 4 (Q14865947)

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mammalian protein found in Mus musculus

interleukin-4
IGG1 induction factor
B-cell IgG differentiation factor
B-cell stimulatory factor 1
B-cell growth factor 1
Il4
lymphocyte stimulatory factor 1

Language	Label	Description	Also known as
English	Interleukin 4	mammalian protein found in Mus musculus	interleukin-4 IGG1 induction factor B-cell IgG differentiation factor B-cell stimulatory factor 1 B-cell growth factor 1 Il4 lymphocyte stimulatory factor 1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

2 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

1 reference

6 July 2017

UniProt protein ID

human chromosome 5

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

strand orientation

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

132673986

human chromosome 5

genomic assembly

genome assembly GRCh38

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

132009678

human chromosome 5

genomic assembly

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

132018368

human chromosome 5

genomic assembly

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

132682678

human chromosome 5

genomic assembly

genome assembly GRCh38

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

cytogenetic location

5q31.1

1 reference

15 May 2022

biological process

extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

9 May 2019

The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

regulation of immune response

determination method

1 reference

9 May 2019

T-bet regulates T-independent IgG2a class switching

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2019

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of B cell activation

determination method

3 references

9 May 2019

Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

Differential requirements of CD45 for lymphocyte development and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of T cell activation

determination method

1 reference

9 May 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of T-helper 17 cell differentiation

determination method

1 reference

9 May 2019

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of transcription by RNA polymerase II

determination method

6 references

9 May 2019

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

Interleukin 4 increases type 5 acid phosphatase mRNA expression in murine bone marrow macrophages

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

Enhancer-mediated control of macrophage-specific arginase I expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

defense response to protozoan

determination method

1 reference

9 May 2019

Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous Leishmaniasis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

1 reference

24 April 2018

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07750&geneProductId=UniProtKB:P07750

determination method

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of epithelial cell migration

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of interleukin-13 production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

T-helper 2 cell cytokine production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

myeloid dendritic cell differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of T cell differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of transcription, DNA-templated

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

9 May 2019

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

dendritic cell differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of complement-dependent cytotoxicity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of endothelial cell apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

T cell activation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

microglial cell activation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of defense response to virus by host

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of acute inflammatory response

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of chronic inflammatory response

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of cell population proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

regulation of proton transport

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of interleukin-10 production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of macrophage activation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

negative regulation of nitric oxide biosynthetic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

regulation of inflammatory response

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of mononuclear cell migration

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of reactive oxygen species biosynthetic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of eosinophil chemotaxis

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of gene expression

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of macroautophagy

determination method

1 reference

9 May 2019

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

activation of Janus kinase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of receptor-mediated endocytosis

determination method

1 reference

1 January 2018

IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07750&geneProductId=UniProtKB:P07750

determination method

positive regulation of cold-induced thermogenesis

determination method

1 reference

9 May 2019

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of amyloid-beta clearance

determination method

1 reference

1 January 2018

IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07750&geneProductId=UniProtKB:P07750

determination method

B cell activation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of cellular respiration

determination method

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

positive regulation of ATP biosynthetic process

determination method

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07750

determination method

491

1 reference

15 May 2022

Gene Atlas image

PBB GE IL4 207538 at fs.png
732 × 530; 12 KB

0 references

PBB GE IL4 207539 s at fs.png
732 × 530; 12 KB

0 references

1 reference

HomoloGene build68

491

1 reference

HomoloGene build68

491

1

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

secondary oocyte

2

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

right uterine tube

3

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

4

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

anterior pituitary

5

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

right coronary artery

6

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

bone marrow cells

7

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

canal of the cervix

8

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

ascending aorta

9

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

10

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000113520

http://identifiers.org/ncbigene/3565

1 reference

Identifiers.org

http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069

Interleukin-4/interleukin-13, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07750

Commons category

Interleukin-4 (IL-4)

0 references

Identifiers

National Library of Israel J9U ID

987007536902705171

1 reference

National Library of Israel Names and Subjects Authority File

Library of Congress authority ID

1 reference

https://github.com/JohnMarkOckerbloom/ftl/blob/master/data/wikimap

3 April 2019

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

BNCF Thesaurus ID

0 references

Ensembl protein ID

ENSMUSP00000000889

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000000889

ENSMUSP00000133617

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000133617

ENSMUSP00000134414

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000134414

Ensembl transcript ID

ENST00000622422

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

ENST00000231449

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

ENST00000350025

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

ENST00000495905

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000113520

0 references

Microsoft Academic ID

0 references

0 references

1 reference

Online Mendelian Inheritance in Man

19 August 2019

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Interleukin-4 (IL-4)

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