cyclin dependent kinase 1 (Q1147372)

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mammalian protein found in Homo sapiens
  • cell cycle controller CDC2
  • cell division control protein 2 homolog
  • p34 protein kinase
  • cyclin-dependent kinase 1
  • cell division protein kinase 1
  • CDK1
  • cell division cycle 2, G1 to S and G2 to M
edit
Language Label Description Also known as
English
cyclin dependent kinase 1
mammalian protein found in Homo sapiens
  • cell cycle controller CDC2
  • cell division control protein 2 homolog
  • p34 protein kinase
  • cyclin-dependent kinase 1
  • cell division protein kinase 1
  • CDK1
  • cell division cycle 2, G1 to S and G2 to M

Statements

image
CDK1 .png
2,100 × 2,100; 2.93 MB
0 references
molecular function
protein binding
determination method
IPI
34 references
retrieved
1 January 2018
stated in
The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Simian virus 40 large T antigen affects the Saccharomyces cerevisiae cell cycle and interacts with p34CDC28
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Cell death in leukemia: passenger protein regulation by topoisomerase inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Sulforaphane, a Dietary Isothiocyanate, Induces G₂/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45β/CDC2 Association
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
retrieved
1 January 2018
stated in
Comparative Proteomics Reveals Important Viral-Host Interactions in HCV-Infected Human Liver Cells
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IPI
cyclin-dependent protein serine/threonine kinase activity
determination method
IDA
IEA
IMP
TAS
6 references
retrieved
31 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493
determination method
TAS
retrieved
31 October 2017
stated in
Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493
determination method
IMP
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493
determination method
IEA
retrieved
31 October 2017
stated in
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493
determination method
IDA
retrieved
31 October 2017
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493
determination method
IDA
cyclin-dependent protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
IMP
TAS
8 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
TAS
retrieved
1 January 2018
stated in
Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IEA
retrieved
1 January 2018
stated in
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IDA
retrieved
1 January 2018
stated in
The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IDA
retrieved
1 January 2018
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P06493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493
determination method
IBA
cell component
biological process
Gene Atlas image
PBB GE CDC2 203213 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D016203
subject named as
CDC2 Protein Kinase
0 references
 
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