simfastatin (Q670131)

[(1S,3R,7S,8R,8aS)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate ^Saesneg

Gene Ontology release 2019-11-16 ^Saesneg

defnydd

cyffur meddygol

0 ffynonellau

adeiledd gemegol

Simvastatin Structural Formulae.svg
471 × 358; 43 KB

0 ffynonellau

stereoisomer of ^Saesneg

2 ffynonellau

inferred from InChIKey ^Saesneg

inferred from InChI ^Saesneg

fformwla gemegol

C₂₅H₃₈O₅

1 ffynhonnell

simvastatin (Saesneg)

18 Tachwedd 2016

SMILES

CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C

1 ffynhonnell

simvastatin (Saesneg)

18 Tachwedd 2016

isomeric SMILES ^Saesneg

CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C

1 ffynhonnell

simvastatin (Saesneg)

18 Tachwedd 2016

defined daily dose ^Saesneg

30 milligram

dull gweini

gweini genau

1 ffynhonnell

https://www.whocc.no/atc_ddd_index/?code=C10AA01

cynhwysyn actif yn

Flolipid ^Saesneg

1 ffynhonnell

RxNorm ^Saesneg

RxNorm CUI ^Saesneg

1944257

14 Chwefror 2018

Zocor ^Saesneg

1 ffynhonnell

RxNorm ^Saesneg

RxNorm CUI ^Saesneg

196503

14 Chwefror 2018

World Health Organisation international non-proprietary name ^Saesneg

simvastatin (Saesneg)

2 ffynonellau

ChEBI

ChEBI ID ^Saesneg

9150

simvastatin (Saesneg)

cyhoeddwyd fel rhan o’r canlynol

3 Hydref 2016

Recommended INN: List 28 ^Saesneg

dyddiad cyhoeddi

1988

found in taxon ^Saesneg

Aspergillus udagawae

1 ffynhonnell

Methylsulfonylated Polyketides Produced by Neosartorya udagawae HDN13-313 via Exogenous Addition of Small Molecules ^Saesneg

Neosartorya udagawae

1 ffynhonnell

Methylsulfonylated Polyketides Produced by Neosartorya udagawae HDN13-313 via Exogenous Addition of Small Molecules ^Saesneg

clefyd a drinir

hypertriglyceridemia ^Saesneg

1 ffynhonnell

13 Rhagfyr 2016

familial hyperlipidemia ^Saesneg

1 ffynhonnell

13 Rhagfyr 2016

1 ffynhonnell

clefyd y rhydwelïau coronaidd

13 Rhagfyr 2016

1 ffynhonnell

13 Rhagfyr 2016

lipedema ^Saesneg

1 ffynhonnell

Drug Indications Extracted from FAERS ^Saesneg

2 Hydref 2018

significant drug interaction ^Saesneg

amiodaron

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

amprenafir

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

atasanafir

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

clarithromycin

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

darunavir ^Saesneg

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

diltiasem

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

erythromycin

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

fflwconasol

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

cetoconasol

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

lopinafir

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

neffasodon

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

nelffinafir

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

ritonafir

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

sacwinafir

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

telithromycin ^Saesneg

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

tipranavir ^Saesneg

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

ferapamil

1 ffynhonnell

High-priority drug–drug interactions for use in electronic health records ^Saesneg

colchicinum

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ffenoffibrad

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ciprofibrate ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

amiodaron

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

danasol

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

gemffibrosil

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

(2R)-daptomycin ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

side effect ^Saesneg

hepatotoxicity ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

carbamasepin

side effect ^Saesneg

hepatotoxicity ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

bezafibrate ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

colchicinum

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

danasol

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ffenoffibrad

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

erythromycin

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

erythromycin

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ritonafir

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ritonafir

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

clarithromycin

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

clarithromycin

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ciclosporin

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ciclosporin

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ciprofibrate ^Saesneg

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

cetoconasol

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

cetoconasol

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ferapamil

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ferapamil

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

amiodaron

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

diltiasem

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

diltiasem

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

amlodipin

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

amlodipin

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ranolazine ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

eltrombopag ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

eltrombopag ^Saesneg

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

cobicistat ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

cobicistat ^Saesneg

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

idelalisib ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

idelalisib ^Saesneg

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

(2R)-daptomycin ^Saesneg

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

bezafibrate ^Saesneg

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

gemffibrosil

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

posaconazole ^Saesneg

side effect ^Saesneg

rhabdomyolysis ^Saesneg

1 ffynhonnell

established ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

posaconazole ^Saesneg

side effect ^Saesneg

muscular disease ^Saesneg

1 ffynhonnell

established ^Saesneg

adweithia'n ffisegol gyda

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

HMGCR

rôl y pwnc

enzyme inhibitor ^Saesneg

1 ffynhonnell

dynodwr Llawlyfr Ffarmacoleg Ligand

IUPHAR/BPS Guide to PHARMACOLOGY ^Saesneg

2955

17 Awst 2016

legal status (medicine) ^Saesneg

boxed warning ^Saesneg

1 ffynhonnell

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

categori beichiogrwydd Awstralia D

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (Saesneg)

categori beichiogrwydd

1 ffynhonnell

mewnforiwyd o

Wicipedia Saesneg

categori beichiogrwydd Unol Daleithiau America X

1 ffynhonnell

mewnforiwyd o

Wicipedia Saesneg

LiverTox likelihood score ^Saesneg

LiverTox toxicity likelihood category A ^Saesneg

1 ffynhonnell

8 Ebrill 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Simvastatin

last update ^Saesneg

5 Awst 2017

màs

418.272 uned Dalton

1 ffynhonnell

InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1

simvastatin (Saesneg)

18 Tachwedd 2016

2 ffynonellau

5 Mawrth 2018

15 Mawrth 2018

hypolipidemic ^Saesneg

1 ffynhonnell

15 Mawrth 2018

anticholesteremic agents ^Saesneg

1 ffynhonnell

15 Mawrth 2018

0 ffynonellau

0 ffynonellau

0 ffynonellau

Simvastatin

0 ffynonellau

Identifiers

InChI

1 ffynhonnell

simvastatin (Saesneg)

18 Tachwedd 2016

InChIKey ^Saesneg

2 ffynonellau

simvastatin (Saesneg)

18 Tachwedd 2016

ChEBI release 2020-09-01 ^Saesneg

Rhif Cofrestru CAS

79902-63-9

2 ffynonellau

UNII ^Saesneg

simvastatin (Saesneg)

18 Tachwedd 2016

InChIKey ^Saesneg

CAS Common Chemistry ^Saesneg

10 Ebrill 2021

https://commonchemistry.cas.org/detail?cas_rn=79902-63-9

ChemSpider ID ^Saesneg

49179

1 ffynhonnell

ChemSpider

ChemSpider ID ^Saesneg

49179

(+)-Simvastatin (Saesneg)

18 Tachwedd 2016

2 ffynonellau

simvastatin (Saesneg)

18 Tachwedd 2016

InChIKey ^Saesneg

Reaxys registry number ^Saesneg

4768037

1 ffynhonnell

ChEBI

ChEBI ID ^Saesneg

9150

simvastatin (Saesneg)

3 Hydref 2016

ChEBI ID ^Saesneg

9150

mapping relation type ^Saesneg

exact match ^Saesneg

2 ffynonellau

ChEMBL ^Saesneg

ChEMBL ID ^Saesneg

CHEMBL1064

SIMVASTATIN (Saesneg)

18 Tachwedd 2016

International Chemical Identifier

InChI

InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1

ChEMBL ID ^Saesneg

CHEMBL1064

1 ffynhonnell

ChEMBL ^Saesneg

ChEMBL ID ^Saesneg

CHEMBL1064

SIMVASTATIN (Saesneg)

18 Tachwedd 2016

SureChEMBL ID ^Saesneg

2471

2 ffynonellau

inferred from InChIKey ^Saesneg

InChIKey ^Saesneg

UniChem compound ID ^Saesneg

21972

1 ffynhonnell

MSBNK-Athens_Univ-AU112801

UniChem

MassBank accession ID ^Saesneg

0 ffynonellau

MSBNK-Athens_Univ-AU112802

0 ffynonellau

MSBNK-Athens_Univ-AU112803

0 ffynonellau

MSBNK-Athens_Univ-AU112804

0 ffynonellau

MSBNK-Athens_Univ-AU112805

0 ffynonellau

0 ffynonellau

0 ffynonellau

0 ffynonellau

0 ffynonellau

0 ffynonellau

0 ffynonellau

SPLASH ^Saesneg

splash10-006w-0790000000-4f23e0376d85845e0964

0 ffynonellau

splash10-05i1-0940000000-058f6298af54c05532ed

0 ffynonellau

splash10-0092-0910000000-6ecd838b2f6fddf67dad

0 ffynonellau

splash10-0597-0900000000-012d0d6fcabbd21d696d

0 ffynonellau

splash10-000e-0590000000-7f99e0b9531d4f42831a

0 ffynonellau

splash10-0092-1960000000-e8429bbec985c5ecdd2d

0 ffynonellau

splash10-0592-1910000000-dc09a51ca37fe4d24a5a

0 ffynonellau

splash10-0abd-1900000000-9b55821f49270e5dd598

0 ffynonellau

splash10-0536-1900000000-d8a41a97ccbdb30e5a5e

0 ffynonellau

splash10-002f-2900000000-abe04d7f99c3eb0f2fcb

0 ffynonellau

splash10-0006-0000900000-7f9cb5f83c393a4262cb

0 ffynonellau

splash10-010a-0980000000-65c631834486c03b85a7

0 ffynonellau

splash10-0a4i-3900000000-d04758924bf88a90c017

0 ffynonellau

NMRShiftDB structure ID ^Saesneg

20168321

1 ffynhonnell

InChIKey ^Saesneg

dynodwr HSDB

7208

1 ffynhonnell

Hazardous Substances Data Bank ^Saesneg

28 Hydref 2019

Simvastatin (Saesneg)

10 Mai 2021

DSSTox substance ID ^Saesneg

DTXSID0023581

2 ffynonellau

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard ^Saesneg

InChIKey ^Saesneg

DSSTOX compound identifier ^Saesneg

DTXCID103581

0 ffynonellau

LiverTox ID ^Saesneg

Simvastatin

0 ffynonellau

NSC number ^Saesneg

758706

0 ffynonellau

EC number ^Saesneg

616-751-8

0 ffynonellau

ECHA Substance Infocard ID ^Saesneg

100.115.749

1 ffynhonnell

http://echa.europa.eu/de/information-on-chemicals/registered-substances

Cod yr ATC

C10AA01

1 ffynhonnell

Dynodwr Drugbank (Alberta)

DrugBank ^Saesneg

DB00641

Simvastatin (Saesneg)

dyddiad cyhoeddi

17 Tachwedd 2015

World Health Organisation international non-proprietary name numeric ID ^Saesneg

6147

1 ffynhonnell

https://mednet-communities.net/inn/db/ViewINN.aspx?i=6147

dynodwr Llawlyfr Ffarmacoleg Ligand

2955

1 ffynhonnell

dynodwr Llawlyfr Ffarmacoleg Ligand

IUPHAR/BPS Guide to PHARMACOLOGY ^Saesneg

2955

D02.455.426.559.847.638.400.900

simvastatin (Saesneg)

18 Tachwedd 2016

Simvastatin

1 ffynhonnell

14 Mawrth 2018

0 ffynonellau

0 ffynonellau

RxNorm CUI ^Saesneg

36567

1 ffynhonnell

UNII ^Saesneg

simvastatin (Saesneg)

Dynodwr Drugbank (Alberta)

18 Tachwedd 2016

DB00641

1 ffynhonnell

InChIKey ^Saesneg

dynodwr HMDB

HMDB0005007

2 ffynonellau

inferred from InChIKey ^Saesneg

InChIKey ^Saesneg

UNII ^Saesneg

2 ffynonellau

UNII ^Saesneg

simvastatin (Saesneg)

18 Tachwedd 2016

InChIKey ^Saesneg

PatientsLikeMe treatment ID

MedlinePlus drug identifier ^Saesneg

a692030

0 ffynonellau

0 ffynonellau

1 ffynhonnell

UNII ^Saesneg

simvastatin (Saesneg)

18 Tachwedd 2016

Probes And Drugs ID ^Saesneg

PD001216

0 ffynonellau

DrugCentral ID ^Saesneg

1 ffynhonnell

1 ffynhonnell

ChEBI ID ^Saesneg

simvastatin (Saesneg)

3 Hydref 2016

CA PROP 65 ID ^Saesneg

simvastatin

1 ffynhonnell

California Proposition 65 list of chemicals ^Saesneg

7 Ionawr 2020

https://oehha.ca.gov/chemicals/simvastatin

CAB ID ^Saesneg

268964

1 ffynhonnell

CABI Thesaurus ^Saesneg

dynodwr Microsoft Academic

6 Ebrill 2020

DeCS ID ^Saesneg

33420

0 ffynonellau

electronic Essential Medicines List medicine ID ^Saesneg

0 ffynonellau

1 ffynhonnell

Freebase Data Dumps ^Saesneg

dyddiad cyhoeddi

28 Hydref 2013

dynodwr ILI

i58957

0 ffynonellau

2776329913

0 ffynonellau

OpenAlex ID ^Saesneg

1 ffynhonnell

26 Ionawr 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

UMLS CUI ^Saesneg

C0074554

1 ffynhonnell

UNII ^Saesneg

simvastatin (Saesneg)

18 Tachwedd 2016

C0733683

1 ffynhonnell

inferred by common MeSH mappings on source and on Wikidata ^Saesneg

UMLS 2023 ^Saesneg

25 Mai 2023

Wellcome Collection concept ID ^Saesneg

e2278hh7

0 ffynonellau

WikiProjectMed ID ^Saesneg

Simvastatin

0 ffynonellau

WordNet 3.1 Synset ID ^Saesneg

04229061-n

1 ffynhonnell