Wikidata:Property proposal/inverse agonist of

From Wikidata
Jump to navigation Jump to search

inverse agonist of[edit]

Return to Wikidata:Property proposal/Natural science

   Under discussion
DescriptionA chemical whose binding to a protein produces the opposite response as an agonist binding to that protein is an inverse agonist to that protein.
Data typeItem
Domaininverse agonist (Q1671731)
Allowed valuesWikidata items of instance of (P31)/subclass of (P279): chemical compound (Q11173), protein (Q8054), or protein family (Q417841)
Example 1pimavanserin (Q7194603)HTR2A (Q14891424)
Example 2pimavanserin tartrate (Q27284759)HTR2A (Q14891424)
Example 3SR9243 (Q27162823)Liver X receptor (Q3454539)
Example 4SR9243 (Q27162823)NR1H2 (Q18032292)
Example 5SR9243 (Q27162823)NR1H3 (Q18034995)
SourceGuide to Pharmacology, ChEMBL, BindingDB, PDB, ChEBI

Motivation[edit]

Other pharmacological relationships (e.g., agonist of (P3772), antagonist of (P3773), positive allosteric modulator of (P3778)) have already been assigned Wikidata properties and there is ongoing work to incorporate more relationships into the OBO Relation Ontology (https://github.com/oborel/obo-relations/issues/369, https://github.com/oborel/obo-relations/issues/371). Inverse agonism is another mechanism of action that's a bit less common than the others, but is very interesting. We want to upload a lot of relations inferred from ChEBI based on manual curation from https://github.com/chemical-roles/chemical-roles and this relation will support encoding some of those.  – The preceding unsigned comment was added by Cthoyt (talk • contribs)..

Discussion[edit]

  • @Cthoyt: The description should define the term inverse agonist instead of just repeating it. ChristianKl❫ 18:14, 20 June 2020 (UTC)