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Fas associated via death domain (Q994646)

From Wikidata
mammalian protein found in Homo sapiens
  • growth-inhibiting gene 3 protein
  • FADD
  • Mediator of receptor induced toxicity
  • FAS-associated death domain protein
  • Fas (TNFRSF6)-associated via death domain
  • Fas-associating death domain-containing protein
  • Protein FADD
  • Fas-associating protein with death domain
  • mediator of receptor-induced toxicity
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    English
    Fas associated via death domain
    mammalian protein found in Homo sapiens
    • growth-inhibiting gene 3 protein
    • FADD
    • Mediator of receptor induced toxicity
    • FAS-associated death domain protein
    • Fas (TNFRSF6)-associated via death domain
    • Fas-associating death domain-containing protein
    • Protein FADD
    • Fas-associating protein with death domain
    • mediator of receptor-induced toxicity

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    45 references
    retrieved
    9 May 2019
    stated in
    Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13158
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13158
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13158
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13158
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Casper is a FADD- and caspase-related inducer of apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13158
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caveolin-1 mediates Fas–BID signaling in hyperoxia-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The apoptotic signaling pathway activated by Toll-like receptor-2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A type III effector antagonizes death receptor signalling during bacterial gut infection
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The Fas-FADD death domain complex structure unravels signalling by receptor clustering
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Yes and PI3K bind CD95 to signal invasion of glioblastoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The role of receptor internalization in CD95 signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    TNF-alpha induces two distinct caspase-8 activation pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
    determination method or standard
    IPI
    cell component
    biological process
    Gene Atlas image
    PBB GE FADD 202535 at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    UniProt protein ID
    Q13158
    0 references
     
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