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WASP actin nucleation promoting factor (Q8027658)

From Wikidata

mammalian protein found in Homo sapiens

eczema-thrombocytopenia
uniprot:P42768
thrombocytopenia 1 (X-linked)
WAS
wiskott-Aldrich syndrome protein

Language	Label	Description	Also known as
default for all languages	No label defined
English	WASP actin nucleation promoting factor	mammalian protein found in Homo sapiens	eczema-thrombocytopenia uniprot:P42768 thrombocytopenia 1 (X-linked) WAS wiskott-Aldrich syndrome protein

Statements

1 reference

13 November 2019

UniProt protein ID

CRIB domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42768

Wiskott-Aldrich syndrome protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42768

Wiscott-Aldrich syndrome protein, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42768

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42768

WH1/EVH1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CRIB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WASP family, EVH1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phospholipase binding

determination method or standard

1 reference

8 April 2019

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

GTPase regulator activity

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

SH3 domain binding

determination method or standard

protein binding

determination method or standard

20 references

8 April 2019

The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain in the presence of WIP

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

A human MAP kinase interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Phosphorylation of WASp is a key regulator of activity and stability in vivo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Activation of endogenous Cdc42 visualized in living cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

identical protein binding

determination method or standard

4 references

8 April 2019

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

protein kinase binding

determination method or standard

1 reference

8 April 2019

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

small GTPase binding

determination method or standard

actin filament binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

cell-cell junction

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

vesicle membrane

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

actin cytoskeleton

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

extracellular exosome

determination method or standard

1 reference

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

determination method or standard

1 reference

17 October 2017

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

8 April 2019

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

determination method or standard

actin cortical patch

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

site of double-strand break

determination method or standard

1 reference

8 April 2019

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

phagocytic vesicle

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

extracellular exosome

determination method or standard

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

biological process

defense response

determination method or standard

1 reference

8 April 2019

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

Fc-gamma receptor signaling pathway involved in phagocytosis

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

actin filament organization

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

negative regulation of cell motility

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

blood coagulation

determination method or standard

1 reference

8 April 2019

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

positive regulation of Arp2/3 complex-mediated actin nucleation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

actin filament-based movement

determination method or standard

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768

determination method or standard

endosomal transport

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

actin filament polymerization

determination method or standard

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768

determination method or standard

regulation of T cell antigen processing and presentation

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

immune response

determination method or standard

1 reference

8 April 2019

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

epidermis development

determination method or standard

1 reference

8 April 2019

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

T cell receptor signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

T cell activation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

regulation of catalytic activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

Rho protein signal transduction

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

regulation of actin polymerization or depolymerization

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

regulation of lamellipodium assembly

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

Cdc42 protein signal transduction

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

regulation of stress fiber assembly

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

negative regulation of stress fiber assembly

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

actin cortical patch assembly

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

positive regulation of actin nucleation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

actin cortical patch localization

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

protein-containing complex assembly

determination method or standard

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

cellular response to interferon-gamma

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

positive regulation of double-strand break repair via homologous recombination

determination method or standard

1 reference

8 April 2019

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

regulation of double-strand break repair via nonhomologous end joining

determination method or standard

1 reference

8 April 2019

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

determination method or standard

Gene Atlas image

PBB GE WAS 38964 r at fs.png
732 × 530; 11 KB

0 references

Commons category

Wiskott-Aldrich syndrome

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000365891

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000365891

ENSP00000410537

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000410537

0 references

Microsoft Academic ID (discontinued)

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(12 entries)

arwiki بروتين متلازمة ويسكوت-ألدريتش
cawiki Proteïna de la síndrome de Wiskott-Aldrich
cywiki WAS
dewiki Wiskott-Aldrich-Syndrom-Protein
enwiki Wiskott–Aldrich syndrome protein
frwiki Protéine du syndrome de Wiskott-Aldrich
glwiki Proteína da síndrome de Wiskott-Aldrich
idwiki Protein Wiskott–Aldrich syndrome
ptwiki Proteína da síndrome de Wiskott-Aldrich
ruwiki Белок синдрома Вискотта — Олдрича
ttwiki WAS
ukwiki WAS

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Wiskott-Aldrich syndrome protein

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