Wnt family member 4 (Q7953610)

http://www.ebi.ac.uk/interpro/protein/P56705

Wnt protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signaling receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

receptor ligand activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56705&geneProductId=UniProtKB:P56705

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

IC

receptor ligand activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

endocytic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

endoplasmic reticulum lumen

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

TAS

extracellular exosome

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

non-canonical Wnt signaling pathway

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

T cell differentiation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of canonical Wnt signaling pathway

2 references

21 June 2018

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56705&geneProductId=UniProtKB:P56705

21 June 2018

Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56705&geneProductId=UniProtKB:P56705

negative regulation of male gonad development

1 reference

8 April 2019

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

IMP

mesonephros development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

androgen biosynthetic process

1 reference

16 July 2018

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56705&geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of wound healing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

metanephros development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

cellular response to transforming growth factor beta stimulus

1 reference

8 April 2019

Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of collagen biosynthetic process

1 reference

8 April 2019

Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

mesonephric tubule development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

mammary gland epithelium development

1 reference

8 April 2019

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

Characterization and expression of the human WNT4; lack of associated germline mutations in high--to moderate--risk breast and ovarian cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

metanephric nephron morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

female sex determination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

smooth muscle cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of transcription, DNA-templated

5 references

8 April 2019

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of GTPase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

branching involved in ureteric bud morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

thyroid-stimulating hormone-secreting cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

hormone metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of steroid biosynthetic process

tertiary branching involved in mammary gland duct morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

male gonad development

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of aldosterone biosynthetic process

1 reference

8 April 2019

Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of bone mineralization

1 reference

8 April 2019

Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

anatomical structure development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

somatotropin secreting cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of testicular blood vessel morphogenesis

1 reference

8 April 2019

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

metanephric mesenchymal cell differentiation

IMP

1 reference

8 April 2019

PAX2 activates WNT4 expression during mammalian kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

metanephric nephron development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of osteoblast differentiation

1 reference

8 April 2019

Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

renal vesicle formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

regulation of cell-cell adhesion

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

epithelial to mesenchymal transition

1 reference

8 April 2019

Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

canonical Wnt signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of transcription, DNA-templated

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

branching morphogenesis of an epithelial tube

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

metanephric tubule formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

non-canonical Wnt signaling pathway via MAPK cascade

1 reference

8 April 2019

Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

embryonic epithelial tube formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of cortisol biosynthetic process

1 reference

8 April 2019

Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of dermatome development

1 reference

8 April 2019

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

cellular response to starvation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

adrenal gland development

1 reference

8 April 2019

Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of fibroblast growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

renal vesicle induction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of meiotic nuclear division

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of focal adhesion assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

1 reference

8 April 2019

Characterization and expression of the human WNT4; lack of associated germline mutations in high--to moderate--risk breast and ovarian cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

immature T cell proliferation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

positive regulation of stress fiber assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

mesenchymal to epithelial transition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

Wnt signaling pathway

regulation of signaling receptor activity

TAS

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

female gonad development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

Wnt signaling pathway

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

negative regulation of androgen biosynthetic process

IBA

1 reference

8 April 2019

WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56705

Wnt protein, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0