MPL proto-oncogene, thrombopoietin receptor (Q7798344)

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mammalian protein found in Homo sapiens

myeloproliferative leukemia protein
thrombopoietin receptor
MPL
TPO-R
myeloproliferative leukemia virus oncogene
proto-oncogene c-Mpl
Receptors, Thrombopoietin

Language	Label	Description	Also known as
English	MPL proto-oncogene, thrombopoietin receptor	mammalian protein found in Homo sapiens	myeloproliferative leukemia protein thrombopoietin receptor MPL TPO-R myeloproliferative leukemia virus oncogene proto-oncogene c-Mpl Receptors, Thrombopoietin

Statements

1 reference

13 November 2019

UniProt protein ID

Fibronectin type III superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P40238

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P40238

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Growth hormone/erythropoietin receptor, ligand binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Long hematopoietin receptor, single chain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

protein binding

determination method

1 reference

8 April 2019

Mpl traffics to the cell surface through conventional and unconventional routes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

transmembrane signaling receptor activity

determination method

1 reference

1 January 2018

Structure and transcription of the human c-mpl gene (MPL)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

thrombopoietin receptor activity

determination method

1 reference

8 April 2019

The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

8 April 2019

The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

integral component of plasma membrane

determination method

1 reference

1 January 2018

Structure and transcription of the human c-mpl gene (MPL)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

determination method

2 references

neuron projection

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

biological process

cell surface receptor signaling pathway

determination method

1 reference

1 January 2018

Structure and transcription of the human c-mpl gene (MPL)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

cell population proliferation

determination method

1 reference

1 January 2018

Structure and transcription of the human c-mpl gene (MPL)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

thrombopoietin-mediated signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

neutrophil homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

monocyte homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

positive regulation of lymphocyte proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

platelet aggregation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

cellular response to hypoxia

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

positive regulation of platelet formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

eosinophil homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

basophil homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40238

determination method

physically interacts with

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201832

Gene Atlas image

PBB GE MPL 211903 s at fs.png
732 × 530; 12 KB

0 references

http://purl.uniprot.org/uniprot/P40238

1 reference

Identifiers.org

Long hematopoietin receptor, single chain, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P40238

fibronectin type III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P40238

Growth hormone/erythropoietin receptor, ligand binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P40238

Identifiers

MeSH descriptor ID

subject named as

Receptors, Thrombopoietin

0 references

D12.776.543.750.705.852.610

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000361548

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361548

ENSP00000414004

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000414004

ENSP00000495154

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495154

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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