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Telomerase reverse transcriptase (Q7697809)

From Wikidata
mammalian protein found in Homo sapiens
  • telomerase-associated protein 2
  • TP2
  • telomerase reverse transcriptase
  • telomerase catalytic subunit
  • TERT
  • HEST2
  • TERT protein, human
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    English
    Telomerase reverse transcriptase
    mammalian protein found in Homo sapiens
    • telomerase-associated protein 2
    • TP2
    • telomerase reverse transcriptase
    • telomerase catalytic subunit
    • TERT
    • HEST2
    • TERT protein, human

    Statements

    molecular function
    telomerase RNA reverse transcriptase activity
    determination method or standard
    IDA
    TAS
    IMP
    IEA
    7 references
    retrieved
    16 July 2018
    stated in
    Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    16 July 2018
    stated in
    Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IPI
    23 references
    retrieved
    8 April 2019
    stated in
    The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Involvement of telomerase reverse transcriptase in heterochromatin maintenance
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    HPV E6 protein interacts physically and functionally with the cellular telomerase complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Telomerase modulates Wnt signalling by association with target gene chromatin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PML-IV functions as a negative regulator of telomerase by interacting with TERT
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional conservation of the telomerase protein Est1p in humans
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere Elongation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human Ku70/80 associates physically with telomerase through interaction with hTERT
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GNL3L stabilizes the TRF1 complex and promotes mitotic transition
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    telomerase RNA binding
    determination method or standard
    IDA
    IEA
    IPI
    7 references
    retrieved
    16 July 2018
    stated in
    Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled In Vivo
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    Human telomerase contains two cooperating telomerase RNA molecules
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    telomerase activity
    determination method or standard
    IEA
    IDA
    TAS
    14 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Structure of active dimeric human telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Cryo-EM structure of substrate-bound human telomerase holoenzyme.
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Differential regulation of telomerase activity by six telomerase subunits
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Reconstitution of human telomerase activity in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    High-throughput RNAi screening reveals novel regulators of telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    RNA binding
    determination method or standard
    IEA
    IPI
    6 references
    retrieved
    8 April 2019
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled In Vivo
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IEA
    telomerase RNA reverse transcriptase activity
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    TAS
    8 references
    retrieved
    8 April 2019
    stated in
    Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IBA
    telomerase RNA binding
    determination method or standard
    IBA
    IDA
    IEA
    IPI
    8 references
    retrieved
    8 April 2019
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled In Vivo
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Human telomerase contains two cooperating telomerase RNA molecules
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IBA
    cell component
    telomerase catalytic core complex
    determination method or standard
    IDA
    IEA
    IMP
    IPI
    8 references
    retrieved
    16 July 2018
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    Reconstitution of human telomerase activity in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    telomerase holoenzyme complex
    determination method or standard
    IDA
    IPI
    TAS
    6 references
    retrieved
    8 April 2019
    stated in
    In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    An enhanced H/ACA RNP assembly mechanism for human telomerase RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cryo-EM structure of substrate-bound human telomerase holoenzyme.
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Differential regulation of telomerase activity by six telomerase subunits
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    telomerase catalytic core complex
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    IPI
    9 references
    retrieved
    8 April 2019
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Reconstitution of human telomerase activity in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IBA
    biological process
    telomere maintenance via telomerase
    determination method or standard
    NAS
    IDA
    TAS
    IMP
    9 references
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    16 July 2018
    stated in
    The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    NAS
    retrieved
    16 July 2018
    stated in
    Extension of life-span by introduction of telomerase into normal human cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Cryo-EM structure of substrate-bound human telomerase holoenzyme.
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Reconstitution of human telomerase activity in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    High-throughput RNAi screening reveals novel regulators of telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    telomere maintenance via telomerase
    determination method or standard
    IBA
    IDA
    IMP
    NAS
    TAS
    10 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    Extension of life-span by introduction of telomerase into normal human cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Cryo-EM structure of substrate-bound human telomerase holoenzyme.
    GOA
    curator
    UniProt
    UniProt protein ID
    O14746
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Reconstitution of human telomerase activity in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    High-throughput RNAi screening reveals novel regulators of telomerase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
    determination method or standard
    IBA

    Identifiers

    MeSH descriptor ID
    C509186
    subject named as
    TERT protein, human
    0 references
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q7697809&oldid=2022910684"