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Secreted frizzled related protein 1 (Q7444436)

From Wikidata
mammalian protein found in Homo sapiens
  • secreted frizzled-related protein 1
  • SARP-2
  • SFRP1
  • secreted apoptosis-related protein 2
  • sFRP-1
  • frizzled-related protein
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    English
    Secreted frizzled related protein 1
    mammalian protein found in Homo sapiens
    • secreted frizzled-related protein 1
    • SARP-2
    • SFRP1
    • secreted apoptosis-related protein 2
    • sFRP-1
    • frizzled-related protein

    Statements

    molecular function
    Wnt-protein binding
    determination method or standard
    NAS
    IDA
    IPI
    7 references
    retrieved
    26 September 2017
    stated in
    Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    NAS
    retrieved
    26 September 2017
    stated in
    Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    26 September 2017
    stated in
    Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    26 September 2017
    stated in
    Wnt3a binds to several sFRPs in the nanomolar range
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    26 September 2017
    stated in
    Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    26 September 2017
    stated in
    Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    26 September 2017
    stated in
    Wnt3a binds to several sFRPs in the nanomolar range
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    Wnt-protein binding
    determination method or standard
    IBA
    IDA
    IPI
    NAS
    8 references
    retrieved
    8 April 2019
    stated in
    Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Wnt3a binds to several sFRPs in the nanomolar range
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Wnt3a binds to several sFRPs in the nanomolar range
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IBA
    cell component
    extracellular space
    determination method or standard
    IDA
    IEA
    5 references
    retrieved
    26 September 2017
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IEA
    retrieved
    26 September 2017
    stated in
    Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Regulation of secreted Frizzled-related protein-1 by heparin
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Proteomics characterization of extracellular space components in the human aorta
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    biological process
    negative regulation of transcription, DNA-templated
    determination method or standard
    IDA
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Prostacyclin Inhibits Non-Small Cell Lung Cancer Growth by a Frizzled 9-Dependent Pathway That Is Blocked by Secreted Frizzled-Related Protein 1
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    positive regulation of apoptotic process
    determination method or standard
    IDA
    IMP
    6 references
    retrieved
    8 April 2019
    stated in
    Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    SARPs: A family of secreted apoptosis-related proteins
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    negative regulation of cell population proliferation
    determination method or standard
    IDA
    5 references
    retrieved
    8 April 2019
    stated in
    Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    negative regulation of apoptotic process
    determination method or standard
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    Functional significance of secreted Frizzled-related protein 1 in metastatic renal cell carcinomas
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    negative regulation of Wnt signaling pathway
    determination method or standard
    NAS
    IDA
    IEA
    IMP
    7 references
    retrieved
    8 April 2019
    stated in
    Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Regulation of secreted Frizzled-related protein-1 by heparin
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    negative regulation of canonical Wnt signaling pathway
    determination method or standard
    IEA
    IDA
    IMP
    IGI
    15 references
    retrieved
    26 September 2017
    stated in
    Suppressing Wnt signaling by the hedgehog pathway through sFRP-1
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    26 September 2017
    stated in
    Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    26 September 2017
    stated in
    Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    26 September 2017
    stated in
    Wnt3a binds to several sFRPs in the nanomolar range
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IGI
    retrieved
    26 September 2017
    stated in
    Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IGI
    retrieved
    26 September 2017
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IEA
    retrieved
    26 September 2017
    stated in
    Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    SARPs: A family of secreted apoptosis-related proteins
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N474&geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    negative regulation of canonical Wnt signaling pathway
    determination method or standard
    IBA
    IDA
    IEA
    IGI
    IMP
    16 references
    retrieved
    8 April 2019
    stated in
    Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Suppressing Wnt signaling by the hedgehog pathway through sFRP-1
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Wnt3a binds to several sFRPs in the nanomolar range
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    SARPs: A family of secreted apoptosis-related proteins
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    Q8N474
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N474
    determination method or standard
    IBA
    Gene Atlas image
    PBB GE SFRP1 202037 s at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

     
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