Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells (Q73434298)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11175341%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells (English)

1 reference

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3 November 2019

author name string

Lim SJ

1

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3 November 2019

Lopez-Berestein G

2

1 reference

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3 November 2019

Hung MC

3

1 reference

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3 November 2019

Lupu R

4

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3 November 2019

Tari AM

5

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3 November 2019

publication date

1 December 2000

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3 November 2019

language of work or name

0 references

1 reference

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3 November 2019

volume

19

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3 November 2019

issue

54

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3 November 2019

page(s)

6271-6276

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Mechanism of activation and function of protein kinase B.

3 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

The Son of sevenless Gene Product: a Putative Activator of Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Stimulation of p21 ras upon T-cell activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

PI3K: downstream AKTion blocks apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Identification of heregulin, a specific activator of p185erbB2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Activation of the MAP kinase pathway by the protein kinase raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Heregulin regulation of Akt/protein kinase B in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Inhibition of Grb2 and Crkl proteins results in growth inhibition of Philadelphia chromosome positive leukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Serum predominantly activates MAPK and akt kinases in EGFR- and ErbB2-over-expressing cells, respectively

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Regulation of transcription by MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021

Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204014

7 January 2021