Functionality map analysis of the active site cleft of human thrombin (Q71483760)

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18 October 2019

title

Functionality map analysis of the active site cleft of human thrombin (English)

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18 October 2019

2

M Karplus

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18 October 2019

author name string

P D Grootenhuis

series ordinal

1

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18 October 2019

publication date

1 February 1996

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Journal of Computer - Aided Molecular Design

18 October 2019

language of work or name

English

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published in

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18 October 2019

volume

10

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18 October 2019

issue

1

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18 October 2019

page(s)

1-10

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A strategy for a rational approach to designing synthetic selective inhibitors

18 October 2019

cites work

1 reference

12 December 2020

Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

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12 December 2020

The structure of a complex of recombinant hirudin and human alpha-thrombin

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12 December 2020

Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile

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Pharmacologic Aspects of the Development of Selective Synthetic Thrombin Inhibitors as Anticoagulants

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Stability and specificity of protein-protein interactions: the case of the trypsin-trypsin inhibitor complexes

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12 December 2020

Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6

1 reference

12 December 2020

Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid

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12 December 2020

Peptide-derived transition state analogue inhibitors of thrombin; Synthesis, activity and selectivity

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12 December 2020

The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution

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12 December 2020

Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors

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12 December 2020

Functionality maps of binding sites: a multiple copy simultaneous search method

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12 December 2020

Synthesis and biological activity of ketomethylene pseudopeptide analogues as thrombin inhibitors

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12 December 2020

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

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12 December 2020

Coagulation factors and their inhibitors

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12 December 2020

Natural protein proteinase inhibitors and their interaction with proteinases

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12 December 2020

Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition

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12 December 2020

An automated method for dynamic ligand design

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12 December 2020

Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors

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12 December 2020

The Na+ Binding Site of Thrombin

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12 December 2020

The interaction of thrombin with fibrinogen. A structural basis for its specificity

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12 December 2020

Direct thrombin inhibitors

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12 December 2020

Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin

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12 December 2020

Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A

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12 December 2020

The structures of domains of blood proteins

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12 December 2020

The coagulation cascade: initiation, maintenance, and regulation

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12 December 2020

Multiple copy simultaneous search and construction of ligands in binding sites: application to inhibitors of HIV-1 aspartic proteinase

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12 December 2020

Strategies for inhibiting the effects of thrombin

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12 December 2020

Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs

1 reference

12 December 2020

Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin

1 reference

12 December 2020

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

1 reference

12 December 2020

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes

1 reference

12 December 2020

Structural basis of the activation and action of trypsin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/BF00124460

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/BF00124460

Identifiers

DOI

10.1007/BF00124460

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8786410%20AND%20SRC:MED&resulttype=core&format=json

journals/jcamd/GrootenhuisK96

18 October 2019

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference