Pyruvate dehydrogenase kinase 1 (Q7118823)

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mammalian protein found in Homo sapiens

• PDH kinase 1
• pyruvate dehydrogenase kinase, isoenzyme 1
• Pyruvate dehydrogenase kinase isoform 1
• mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1
• [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
• pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial
• PDK1

edit

Language	Label	Description	Also known as
English	Pyruvate dehydrogenase kinase 1	mammalian protein found in Homo sapiens	PDH kinase 1 pyruvate dehydrogenase kinase, isoenzyme 1 Pyruvate dehydrogenase kinase isoform 1 mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial PDK1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q15118

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q15118

encoded by

PDK1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q15118

molecular function

transferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

nucleotide binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

protein kinase activity

determination method

IDA

TAS

2 references

retrieved

5 June 2018

stated in

Diversity of the pyruvate dehydrogenase kinase gene family in humans

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118

determination method

TAS

retrieved

5 June 2018

stated in

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118

determination method

IDA

kinase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

protein binding

determination method

IPI

3 references

retrieved

8 April 2019

stated in

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IPI

retrieved

8 April 2019

stated in

Mutagenesis studies of the phosphorylation sites of recombinant human pyruvate dehydrogenase. Site-specific regulation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IPI

retrieved

8 April 2019

stated in

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IPI

ATP binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

pyruvate dehydrogenase (acetyl-transferring) kinase activity

determination method

IEA

EXP

IDA

IMP

4 references

retrieved

21 June 2018

stated in

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118

determination method

IMP

retrieved

21 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118

determination method

IEA

retrieved

21 June 2018

stated in

Diversity of the pyruvate dehydrogenase kinase gene family in humans

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118

determination method

IDA

retrieved

21 June 2018

stated in

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118

determination method

EXP

protein kinase activity

determination method

IDA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Diversity of the pyruvate dehydrogenase kinase gene family in humans

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

retrieved

8 April 2019

stated in

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IDA

pyruvate dehydrogenase (acetyl-transferring) kinase activity

determination method

IDA

IEA

IMP

3 references

retrieved

8 April 2019

stated in

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IMP

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

retrieved

8 April 2019

stated in

Diversity of the pyruvate dehydrogenase kinase gene family in humans

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IDA

cell component

mitochondrial pyruvate dehydrogenase complex

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

mitochondrial matrix

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

nucleus

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IDA

nucleolus

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IDA

mitochondrion

determination method

IDA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Diversity of the pyruvate dehydrogenase kinase gene family in humans

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IDA

biological process

intrinsic apoptotic signaling pathway in response to oxidative stress

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IMP

phosphorylation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

hypoxia-inducible factor-1alpha signaling pathway

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IMP

regulation of acetyl-CoA biosynthetic process from pyruvate

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

regulation of glucose metabolic process

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IMP

glucose metabolic process

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

Diversity of the pyruvate dehydrogenase kinase gene family in humans

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

cell population proliferation

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IMP

protein phosphorylation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

carbohydrate metabolic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q15118

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118

determination method

IEA

Gene Atlas image

PBB GE PDK1 206686 at fs.png
732 × 530; 12 KB

0 references

Identifiers

RefSeq protein ID

NP_001265478

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5163

NP_002601

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5163

XP_006712657

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5163

XP_006712658

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5163

XP_011509645

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5163

XP_011509646

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5163

XP_011509647

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5163

XP_011509649

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5163

UniProt protein ID

Q15118

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q15118

Ensembl protein ID

ENSP00000282077

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000282077

ENSP00000376352

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000376352

ENSP00000386985

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386985

ENSP00000388366

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000388366

ENSP00000399160

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000399160

ENSP00000399558

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000399558

ENSP00000406608

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000406608

ENSP00000413629

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000413629

PDB structure ID

2Q8F

1 reference

stated in

UniProt

UniProt protein ID

Q15118

retrieved

9 August 2016

language of work or name

English

2Q8G

1 reference

stated in

UniProt

UniProt protein ID

Q15118

retrieved

9 August 2016

language of work or name

English

2Q8H

1 reference

stated in

UniProt

UniProt protein ID

Q15118

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q7118823&oldid=2022909522"