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SMAD family member 1 (Q699999)

From Wikidata
mammalian protein found in Homo sapiens
  • TGF-beta signaling protein 1
  • mothers against decapentaplegic homolog 1
  • SMAD, mothers against DPP homolog 1
  • transforming growth factor-beta signaling protein 1
  • SMAD 1
  • JV4-1
  • hSMAD1
  • BSP-1
  • mothers against DPP homolog 1
  • MAD, mothers against decapentaplegic homolog 1
  • Mad-related protein 1
  • SMAD1
  • Transforming growth factor-beta-signaling protein 1
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    English
    SMAD family member 1
    mammalian protein found in Homo sapiens
    • TGF-beta signaling protein 1
    • mothers against decapentaplegic homolog 1
    • SMAD, mothers against DPP homolog 1
    • transforming growth factor-beta signaling protein 1
    • SMAD 1
    • JV4-1
    • hSMAD1
    • BSP-1
    • mothers against DPP homolog 1
    • MAD, mothers against decapentaplegic homolog 1
    • Mad-related protein 1
    • SMAD1
    • Transforming growth factor-beta-signaling protein 1

    Statements

    subclass of
    R-SMAD
    0 references
    molecular function
    protein binding
    determination method or standard
    IPI
    22 references
    retrieved
    8 April 2019
    stated in
    Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    USP15 is a deubiquitylating enzyme for receptor-activated SMADs
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural Basis of Smad1 Activation by Receptor Kinase Phosphorylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional proteomics mapping of a human signaling pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Charting the molecular links between driver and susceptibility genes in colorectal cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SMAD proteins control DROSHA-mediated microRNA maturation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SMAD proteins control DROSHA-mediated microRNA maturation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IPI
    cell component
    nucleus
    determination method or standard
    NAS
    IDA
    ISS
    TAS
    IEA
    7 references
    retrieved
    8 April 2019
    stated in
    Holding their own: the noncanonical roles of Smad proteins
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    TGF-beta signal transduction
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    ISS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    MADR1, a MAD-related protein that functions in BMP2 signaling pathways
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IDA
    biological process
    BMP signaling pathway
    determination method or standard
    IDA
    ISS
    TAS
    IMP
    IEA
    9 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Holding their own: the noncanonical roles of Smad proteins
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    ISS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    ISS
    retrieved
    8 April 2019
    stated in
    Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    MADR1, a MAD-related protein that functions in BMP2 signaling pathways
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15797
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    SMAD proteins control DROSHA-mediated microRNA maturation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
    determination method or standard
    IDA
    Gene Atlas image
    PBB GE SMAD1 210993 s at fs.png
    732 × 530; 12 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D051898
    subject named as
    Smad1 Protein
    0 references
     
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