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mitogen-activated protein kinase 14 (Q6714402)

From Wikidata
mammalian protein found in Homo sapiens
  • mitogen-activated protein kinase 14
  • mitogen-activated protein kinase p38 alpha
  • p38 mitogen activated protein kinase
  • Cytokine suppressive anti-inflammatory drug-binding protein
  • stress-activated protein kinase 2A
  • CSBP
  • MAP kinase 14
  • p38alpha Exip
  • MAP kinase Mxi2
  • MAX-interacting protein 2
  • MAP kinase p38 alpha
  • p38 MAP kinase
  • CSAID-binding protein
  • cytokine suppressive anti-inflammatory drug binding protein
  • MAPK14
  • Csaids binding protein
  • SAPK2a
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    English
    mitogen-activated protein kinase 14
    mammalian protein found in Homo sapiens
    • mitogen-activated protein kinase 14
    • mitogen-activated protein kinase p38 alpha
    • p38 mitogen activated protein kinase
    • Cytokine suppressive anti-inflammatory drug-binding protein
    • stress-activated protein kinase 2A
    • CSBP
    • MAP kinase 14
    • p38alpha Exip
    • MAP kinase Mxi2
    • MAX-interacting protein 2
    • MAP kinase p38 alpha
    • p38 MAP kinase
    • CSAID-binding protein
    • cytokine suppressive anti-inflammatory drug binding protein
    • MAPK14
    • Csaids binding protein
    • SAPK2a

    Statements

    molecular function
    MAP kinase activity
    determination method or standard
    IDA
    IEA
    6 references
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IPI
    26 references
    retrieved
    8 April 2019
    stated in
    LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Towards a proteome-scale map of the human protein–protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human MAP kinase interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mxi2 promotes stimulus-independent ERK nuclear translocation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The protein interaction landscape of the human CMGC kinase group
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A directed protein interaction network for investigating intracellular signal transduction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IPI
    MAP kinase activity
    determination method or standard
    IBA
    IDA
    IEA
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16539
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
    determination method or standard
    IBA
    cell component
    biological process
    physically interacts with
    Gene Atlas image
    PBB GE MAPK14 202530 at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D048308
    subject named as
    Mitogen-Activated Protein Kinase 14
    0 references
    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q6714402&oldid=2383229446"