transglutaminase 2 (Q647813)

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mammalian protein found in Homo sapiens

transglutaminase H
protein-glutamine gamma-glutamyltransferase 2
Transglutaminase-2
TGase-2
TG(C)
TGase C
C polypeptide, protein-glutamine-gamma-glutamyltransferase
transglutaminase C
TGM2
TGC
TGase H
tissue transglutaminase
Protein Glutamine gamma Glutamyltransferase 2

Language	Label	Description	Also known as
English	transglutaminase 2	mammalian protein found in Homo sapiens	transglutaminase H protein-glutamine gamma-glutamyltransferase 2 Transglutaminase-2 TGase-2 TG(C) TGase C C polypeptide, protein-glutamine-gamma-glutamyltransferase transglutaminase C TGM2 TGC TGase H tissue transglutaminase Protein Glutamine gamma Glutamyltransferase 2

Statements

1 reference

13 November 2019

UniProt protein ID

Transglutaminase-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21980

Protein-glutamine gamma-glutamyltransferase, animal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21980

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21980

Transglutaminase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21980

Immunoglobulin E-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21980

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21980

Transglutaminase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transglutaminase-like family

1 reference

based on heuristic

inferred from protein domain or family

Transglutaminase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transglutaminase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

acyltransferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

protein-glutamine gamma-glutamyltransferase activity

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

8 April 2019

Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

protein binding

determination method

10 references

9 May 2019

Identification of the eukaryotic initiation factor 5A as a retinoic acid-stimulated cellular binding partner for tissue transglutaminase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Transglutaminase-2 interaction with heparin: identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

The first draft of the endostatin interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Tissue transglutaminase interacts with protein kinase A anchor protein 13 in prostate cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Cancer cells promote survival through depletion of the von Hippel-Lindau tumor suppressor by protein crosslinking

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

The Multimerization State of the Amyloid-β42 Amyloid Peptide Governs its Interaction Network with the Extracellular Matrix

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

protein domain specific binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

protein-glutamine gamma-glutamyltransferase activity

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

intrinsic component of plasma membrane

determination method

2 references

determination method

1 reference

9 May 2019

Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21980&geneProductId=UniProtKB:P21980

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

plasma membrane

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

extracellular matrix

determination method

1 reference

17 October 2017

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21980&geneProductId=UniProtKB:P21980

determination method

determination method

1 reference

9 May 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

collagen-containing extracellular matrix

determination method

4 references

9 May 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

determination method

3 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

biological process

apoptotic cell clearance

determination method

1 reference

9 May 2019

Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

phospholipase C-activating G protein-coupled receptor signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

salivary gland cavitation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

peptide cross-linking

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

branching involved in salivary gland morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

positive regulation of inflammatory response

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

protein homooligomerization

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

blood vessel remodeling

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21980

determination method

Gene Atlas image

PBB GE TGM2 201042 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P21980

1 reference

Identifiers.org

Identifiers

MeSH descriptor ID

subject named as

Protein Glutamine gamma Glutamyltransferase 2

0 references

D08.811.913.050.200.800.650

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000355330

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355330

ENSP00000362502

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362502

ENSP00000387642

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387642

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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