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Interferon regulatory factor 3 (Q5973468)

From Wikidata
mammalian protein found in Homo sapiens
  • uniprot:Q14653
  • IRF3
  • interferon regulatory factor 3
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    English
    Interferon regulatory factor 3
    mammalian protein found in Homo sapiens
    • uniprot:Q14653
    • IRF3
    • interferon regulatory factor 3

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    17 references
    retrieved
    8 April 2019
    stated in
    C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14653
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14653
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14653
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14653
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14653
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal structure of IRF-3 in complex with CBP.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RIOK3 Is an Adaptor Protein Required for IRF3-Mediated Antiviral Type I Interferon Production
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    identical protein binding
    determination method or standard
    IEA
    IPI
    14 references
    retrieved
    1 January 2018
    stated in
    ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural basis for suppression of a host antiviral response by influenza A virus
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Activation of STAT6 by STING is critical for antiviral innate immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IEA
    identical protein binding
    determination method or standard
    IPI
    13 references
    retrieved
    8 April 2019
    stated in
    Structural basis for suppression of a host antiviral response by influenza A virus
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Activation of STAT6 by STING is critical for antiviral innate immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
    determination method or standard
    IPI
    cell component
    biological process
    Gene Atlas image
    PBB GE IRF3 202621 at fs.png
    732 × 530; 12 KB
    0 references

    Identifiers

    RefSeq protein ID
    Ensembl protein ID
    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q5973468&oldid=2022908584"