How do cytotoxic lymphocytes kill their targets? (Q57720900)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

title

How do cytotoxic lymphocytes kill their targets? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

0 references

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

author name string

S Shresta

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

C T Pham

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

D A Thomas

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

T J Ley

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

publication date

1 October 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Immunology

6 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

page(s)

581-587

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

publication type of scholarly work

6 December 2019

review article

1 reference

Mechanism of lymphocyte-mediated cytotoxicity

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Protein sorting and secretion during CTL killing

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

FLICE Induced Apoptosis in a Cell-free System

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Immune function in mice lacking the perforin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Residual Cytotoxicity and Granzyme K Expression in Granzyme A-deficient Cytotoxic Lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Long-range disruption of gene expression by a selectable marker cassette

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Production of Fully Active Recombinant Murine Granzyme B in Yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Expression and Purification of Enzymatically Active Recombinant Granzyme B in a Baculovirus System

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Processing and activation of CMH-1 by granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6

7 January 2021

10.1016/S0952-7915(98)80227-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference