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Inhibitor of nuclear factor kappa B kinase subunit beta (Q571999)

From Wikidata
mammalian protein found in Homo sapiens
  • IKK2
  • IKK-B
  • IKBKB
  • NFKBIKB
  • I-kappa-B kinase 2
  • inhibitor of nuclear factor kappa-B kinase subunit beta
  • I-kappa-B-kinase beta
  • nuclear factor NF-kappa-B inhibitor kinase beta
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
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    English
    Inhibitor of nuclear factor kappa B kinase subunit beta
    mammalian protein found in Homo sapiens
    • IKK2
    • IKK-B
    • IKBKB
    • NFKBIKB
    • I-kappa-B kinase 2
    • inhibitor of nuclear factor kappa-B kinase subunit beta
    • I-kappa-B-kinase beta
    • nuclear factor NF-kappa-B inhibitor kinase beta
    • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    58 references
    retrieved
    1 January 2018
    stated in
    The Zinc Finger Protein ZNF268 Is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Binding of manumycin A inhibits IkappaB kinase beta activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Hepatitis B Virus Polymerase Suppresses NF-κB Signaling by Inhibiting the Activity of IKKs via Interaction with Hsp90β
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Crystal structure of inhibitor of κB kinase β
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A role for IkappaB kinase 2 in bipolar spindle assembly
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Expanding the substantial interactome of NEMO using protein microarrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Viral immune modulators perturb the human molecular network by common and unique strategies
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Inhibition of IkappaB kinase by vaccinia virus virulence factor B14
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Theileria-induced constitutive IKK activation is independent of functional Hsp90
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IPI
    protein serine/threonine kinase activity
    determination method or standard
    EXP
    IBA
    IDA
    IEA
    TAS
    6 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    GOA
    curator
    UniProt
    UniProt protein ID
    O14920
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    IBA
    retrieved
    1 January 2018
    stated in
    IκB kinase phosphorylation of SNAP-23 controls platelet secretion
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    EXP
    retrieved
    1 January 2018
    stated in
    Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
    determination method or standard
    EXP
    cell component
    biological process
    EC enzyme number
    2.7.11.1
    1 reference
    stated in
    UniProt
    UniProt protein ID
    O14920
    retrieved
    23 July 2026
    2.7.11.10
    1 reference
    stated in
    UniProt
    UniProt protein ID
    O14920
    retrieved
    23 July 2026
    Gene Atlas image
    PBB GE IKBKB 209341 s at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    RefSeq protein ID
    Ensembl protein ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q571999&oldid=2521520240"