Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance. (Q55663256)

19 July 2018

1 reference

26 October 2020

Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance. (English)

1 reference

19 July 2018

antineoplastic resistance

1 reference

26 October 2020

1 reference

26 October 2020

1 reference

7 August 2019

1 reference

26 October 2020

1 reference

4

1 reference

19 July 2018

author name string

Ha S Nguyen

1

1 reference

19 July 2018

Saman Shabani

2

1 reference

19 July 2018

Ahmed J Awad

3

1 reference

19 July 2018

Ninh Doan

5

1 reference

19 July 2018

language of work or name

English

0 references

publication date

14 June 2018

7 references

19 July 2018

International Journal of Molecular Sciences

14 March 2019

3 April 2019

25 April 2019

19 June 2019

7 August 2019

26 October 2020

7 references

19 July 2018

14 March 2019

3 April 2019

25 April 2019

19 June 2019

7 August 2019

26 October 2020

19

1 reference

19 July 2018

issue

6

1 reference

19 July 2018

Creative Commons Attribution

copyright license

6 references

14 March 2019

3 April 2019

25 April 2019

19 June 2019

7 August 2019

26 October 2020

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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27 July 2018

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Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner

27 July 2018

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IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival

27 July 2018

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27 July 2018

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27 July 2018

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Molecular targeted therapy in recurrent glioblastoma: current challenges and future directions

27 July 2018

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27 July 2018

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Comparative assessment of 5 methods (methylation-specific polymerase chain reaction, MethyLight, pyrosequencing, methylation-sensitive high-resolution melting, and immunohistochemistry) to analyze O6-methylguanine-DNA-methyltranferase in a series of

27 July 2018

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Ceramide synthases at the centre of sphingolipid metabolism and biology

27 July 2018

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27 July 2018

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27 July 2018

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The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis

27 July 2018

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IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy

27 July 2018

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27 July 2018

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Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness.

27 July 2018

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Recurrent glioblastoma multiforme: a review of natural history and management options

27 July 2018

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27 July 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

27 July 2018

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

27 July 2018

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The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts

27 July 2018

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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

27 July 2018

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27 July 2018

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Ceramide in apoptosis: an overview and current perspectives

27 July 2018

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Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials

27 July 2018

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The significance of the expression of tumor suppressor gene DCC in human gliomas

27 July 2018

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Purification, characterization, and biosynthesis of human acid ceramidase

27 July 2018

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27 July 2018

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Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model.

27 July 2018

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Structural basis for the activation of acid ceramidase.

12 August 2018

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Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges.

12 August 2018

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CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB.

12 August 2018

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Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.

12 August 2018

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Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression.

12 August 2018

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HCFU inhibits cervical cancer cells growth and metastasis by inactivating Wnt/β-catenin pathway.

12 August 2018

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The Role of Hypoxia in Glioblastoma Invasion.

12 August 2018

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A systematic review of perioperative seizure prophylaxis during brain tumor resection: the case for a multicenter randomized clinical trial

12 August 2018

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Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ERα.

12 August 2018

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Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

12 August 2018

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Acid ceramidase confers radioresistance to glioblastoma cells

12 August 2018

1 reference

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Integrating molecular markers into the World Health Organization classification of CNS tumors: a survey of the neuro-oncology community

12 August 2018

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The Role of Molecular Diagnostics in the Management of Patients with Gliomas

12 August 2018

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Epithelial-mesenchymal transition in glioblastoma progression

12 August 2018

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ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

12 August 2018

1 reference

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Epidermal growth factor receptor targeting and challenges in glioblastoma

12 August 2018

1 reference

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Rapid Intraoperative Molecular Characterization of Glioma

12 August 2018

1 reference

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Treatment of elderly patients with glioblastoma: a systematic evidence-based analysis

12 August 2018

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A practical review of prognostic correlations of molecular biomarkers in glioblastoma

12 August 2018

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MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial.

12 August 2018

1 reference

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Targeted molecular therapies against epidermal growth factor receptor: past experiences and challenges

12 August 2018

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CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.

12 August 2018

1 reference

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Advanced magnetic resonance imaging of the physical processes in human glioblastoma

12 August 2018

1 reference

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Use of dexamethasone in patients with high-grade glioma: a clinical practice guideline

12 August 2018

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MGMT testing--the challenges for biomarker-based glioma treatment

12 August 2018

1 reference

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IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients

12 August 2018

1 reference

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Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma

12 August 2018

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A randomized trial of bevacizumab for newly diagnosed glioblastoma

12 August 2018

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Loss of heterozygosity 1p/19q and survival in glioma: a meta-analysis

12 August 2018

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IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection

12 August 2018

1 reference

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A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.

12 August 2018

1 reference

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Transcriptome analysis of glioma cells for the dynamic response to γ-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas

12 August 2018

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Primary glioblastoma with oligodendroglial differentiation has better clinical outcome but no difference in common biological markers compared with other types of glioblastoma

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Considerations in prophylaxis for tumor-associated epilepsy: prevention of status epilepticus and tolerability of newer generation AEDs

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

IDH1/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

An integrated genomic analysis of human glioblastoma multiforme

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

CD133 identifies perivascular niches in grade II-IV astrocytomas.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Stem cell marker CD133 affects clinical outcome in glioma patients.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Patterns of care for adults with newly diagnosed malignant glioma.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Biologically active sphingolipids in cancer pathogenesis and treatment

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Postoperative adjuvant use of carmofur for early breast cancer.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

ENZYMIC HYDROLYSIS AND SYNTHESIS OF CERAMIDES

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Human acid ceramidase is overexpressed but not mutated in prostate cancer

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

[Anti-tumor effects of carmofur on human 5-FU resistant cells]

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6032212

Randomized trial of the efficacy of adjuvant chemotherapy for colon cancer with combination therapy incorporating the oral pyrimidine 1-hexylcarbamoyl-5-fluorouracil

12 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29899215

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Epidemiology of brain tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29899215

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29899215

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/IJMS19061765

1 reference

19 July 2018

PMCID

6032212

1 reference

19 July 2018

PubMed ID

29899215

1 reference

19 July 2018