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Geminin DNA replication inhibitor (Q5530676)

From Wikidata
mammalian protein found in Homo sapiens
  • GMNN
  • geminin
  • uniprot:O75496
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    English
    Geminin DNA replication inhibitor
    mammalian protein found in Homo sapiens
    • GMNN
    • geminin
    • uniprot:O75496

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    15 references
    retrieved
    8 April 2019
    stated in
    Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex
    GOA
    curator
    UniProt
    UniProt protein ID
    O75496
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A WD-Repeat Protein Stabilizes ORC Binding to Chromatin
    GOA
    curator
    UniProt
    UniProt protein ID
    O75496
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Self-assembling protein microarrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Pooled-matrix protein interaction screens using Barcode Fusion Genetics
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496
    determination method or standard
    IPI
    cell component
    biological process
    Gene Atlas image
    PBB GE GMNN 218350 s at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

     
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