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glycogen synthase kinase 3 beta (Q5514576)

From Wikidata
mammalian protein found in Homo sapiens
  • glycogen synthase kinase-3 beta
  • GSK-3 beta
  • GSK3beta isoform
  • serine/threonine-protein kinase GSK3B
  • GSK3B
  • 2.7.11.1
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    English
    glycogen synthase kinase 3 beta
    mammalian protein found in Homo sapiens
    • glycogen synthase kinase-3 beta
    • GSK-3 beta
    • GSK3beta isoform
    • serine/threonine-protein kinase GSK3B
    • GSK3B
    • 2.7.11.1

    Statements

    molecular function
    protein serine/threonine kinase activity
    determination method or standard
    IDA
    ISS
    IEA
    TAS
    11 references
    retrieved
    26 September 2017
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    TAS
    retrieved
    26 September 2017
    stated in
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    ISS
    retrieved
    26 September 2017
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IEA
    retrieved
    26 September 2017
    stated in
    Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IPI
    70 references
    retrieved
    9 May 2019
    stated in
    Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Human Dynamin-like Protein Interacts with the Glycogen Synthase Kinase 3β
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The protein interaction landscape of the human CMGC kinase group
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Oncogenic Function of DACT1 in Colon Cancer through the Regulation of β-catenin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Vimentin is a novel AKT1 target mediating motility and invasion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Stimulatory effect of α‐synuclein on the tau‐phosphorylation by GSK‐3β
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    NOK/STYK1 interacts with GSK‐3β and mediates Ser9 phosphorylation through activated Akt
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A directed protein interaction network for investigating intracellular signal transduction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IPI
    protein serine/threonine kinase activity
    determination method or standard
    IDA
    IEA
    IMP
    ISS
    NAS
    TAS
    15 references
    retrieved
    9 May 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    TAS
    retrieved
    9 May 2019
    stated in
    Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    NAS
    retrieved
    9 May 2019
    stated in
    Roles of tau protein in health and disease
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    NAS
    retrieved
    9 May 2019
    stated in
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    ISS
    retrieved
    9 May 2019
    stated in
    GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IMP
    retrieved
    9 May 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IEA
    retrieved
    9 May 2019
    stated in
    Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    cell component
    cytoplasm
    determination method or standard
    IDA
    IEA
    6 references
    retrieved
    9 May 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IEA
    retrieved
    9 May 2019
    stated in
    ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    beta-catenin destruction complex
    determination method or standard
    IDA
    TAS
    6 references
    retrieved
    9 May 2019
    stated in
    Glycogen synthase kinase 3: more than a namesake
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    TAS
    retrieved
    9 May 2019
    stated in
    Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    TAS
    retrieved
    9 May 2019
    stated in
    Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    biological process
    protein phosphorylation
    determination method or standard
    IDA
    IEA
    TAS
    5 references
    retrieved
    26 September 2017
    stated in
    A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    TAS
    retrieved
    26 September 2017
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IEA
    retrieved
    26 September 2017
    stated in
    ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    26 September 2017
    stated in
    Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    peptidyl-serine phosphorylation
    determination method or standard
    IDA
    5 references
    retrieved
    9 May 2019
    stated in
    Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    protein phosphorylation
    determination method or standard
    IDA
    IEA
    IMP
    TAS
    6 references
    retrieved
    9 May 2019
    stated in
    A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    TAS
    retrieved
    9 May 2019
    stated in
    GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IMP
    retrieved
    9 May 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IEA
    retrieved
    9 May 2019
    stated in
    ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P49841
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
    determination method or standard
    IDA
    Gene Atlas image
    PBB GE GSK3B 209945 s at fs.png
    732 × 530; 12 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D000071679
    subject named as
    Glycogen Synthase Kinase 3 beta
    0 references
    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q5514576&oldid=2383229935"