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Growth factor receptor bound protein 2 (Q5514416)

From Wikidata
mammalian protein found in Homo sapiens
  • growth factor receptor-bound protein 3
  • protein Ash
  • epididymis secretory sperm binding protein
  • abundant SRC homology
  • HT027
  • SH2/SH3 adapter GRB2
  • GRB2
  • epidermal growth factor receptor-binding protein GRB2
  • growth factor receptor-bound protein 2
  • Adapter protein GRB2
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    English
    Growth factor receptor bound protein 2
    mammalian protein found in Homo sapiens
    • growth factor receptor-bound protein 3
    • protein Ash
    • epididymis secretory sperm binding protein
    • abundant SRC homology
    • HT027
    • SH2/SH3 adapter GRB2
    • GRB2
    • epidermal growth factor receptor-binding protein GRB2
    • growth factor receptor-bound protein 2
    • Adapter protein GRB2

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    129 references
    retrieved
    1 January 2018
    stated in
    unc-53 controls longitudinal migration in C. elegans
    GOA
    curator
    WormBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    FCRL6 receptor: expression and associated proteins.
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development
    GOA
    curator
    UniProt
    UniProt protein ID
    P62993
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Charting the molecular network of the drug target Bcr-Abl
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Functional interaction between c-Src and its mitotic target, Sam 68
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A single PXXP motif in the C‐terminal region of srGAP3 mediates binding to multiple SH3 domains
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Characterization of VIK-1: a new Vav-interacting Kruppel-like protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Characterization of interactions of Nck with Sos and dynamin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Subsets of epidermal growth factor receptors during activation and endocytosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Pooled-matrix protein interaction screens using Barcode Fusion Genetics
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Weak binding to E3 ubiquitin ligase c‐Cbl increases EGFRvA protein stability
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A novel proteomic screen for peptide-protein interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A directed protein interaction network for investigating intracellular signal transduction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A THEMIS:SHP1 complex promotes T-cell survival
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Sos-mediated activation of rac1 by p66shc
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Threshold-controlled ubiquitination of the EGFR directs receptor fate
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Two mechanistically distinct forms of endocytosis in adrenal chromaffin cells: Differential effects of SH3 domains and amphiphysin antagonism
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Regulation of Sos Activity by Intramolecular Interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Differential interactions of human Sos1 and Sos2 with Grb2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phospho-tyrosine dependent protein-protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Activation of Src and transformation by an RPTPα splice mutant found in human tumours
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A quantitative protein interaction network for the ErbB receptors using protein microarrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The elucidation of novel SH2 binding sites on PLD2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A human MAP kinase interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    An alternative to phosphotyrosine-containing motifs for binding to an SH2 domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Defining the human deubiquitinating enzyme interaction landscape
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Bcr phosphorylated on tyrosine 177 binds Grb2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Inhibition of basal FGF receptor signaling by dimeric Grb2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A protein domain-based interactome network for C. elegans early embryogenesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
    determination method or standard
    IPI
    cell component
    biological process

    Identifiers

    MeSH descriptor ID
    D051380
    subject named as
    GRB2 Adaptor Protein
    0 references
    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q5514416&oldid=2383222243"