Growth differentiation factor 2 (Q5513077)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

transforming growth factor beta receptor binding

IPI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

Large-scale proteomics and phosphoproteomics of urinary exosomes

cell component

extracellular exosome

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UK05&geneProductId=UniProtKB:Q9UK05

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

regulation of apoptotic process

HDA

biological process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

pathway-restricted SMAD protein phosphorylation

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

positive regulation of endothelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

blood vessel morphogenesis

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

negative regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

SMAD protein signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

positive regulation of pathway-restricted SMAD protein phosphorylation

3 references

17 October 2017

ALK1 signaling regulates early postnatal lymphatic vessel development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UK05&geneProductId=UniProtKB:Q9UK05

17 October 2017

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UK05&geneProductId=UniProtKB:Q9UK05

17 October 2017

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UK05&geneProductId=UniProtKB:Q9UK05

cellular response to BMP stimulus

1 reference

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

negative regulation of DNA replication

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

negative regulation of endothelial cell migration

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

negative regulation of endothelial cell proliferation

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

cartilage development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

positive regulation of osteoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

positive regulation of cartilage development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

negative regulation of cell growth

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

osteoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

positive regulation of interleukin-8 production

1 reference

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

positive regulation of BMP signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

negative regulation of angiogenesis

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

negative regulation of DNA biosynthetic process

1 reference

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

cellular iron ion homeostasis

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

activin receptor signaling pathway

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UK05&geneProductId=UniProtKB:Q9UK05

BMP signaling pathway

3 references

17 October 2017

17 October 2017

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UK05&geneProductId=UniProtKB:Q9UK05

17 October 2017

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UK05&geneProductId=UniProtKB:Q9UK05

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

positive regulation of pathway-restricted SMAD protein phosphorylation

4 references

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

8 April 2019

ALK1 signaling regulates early postnatal lymphatic vessel development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

BMP signaling pathway

4 references

8 April 2019

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UK05

Transforming growth factor-beta, C-terminal

has part(s)

1 reference

Transforming growth factor beta, conserved site

1 reference

TGF-beta, propeptide

1 reference

Identifiers

MeSH descriptor ID

D055427

subject named as

Growth Differentiation Factor 2

0 references

MeSH tree code

D12.644.276.954.200.910

0 references

D12.644.276.954.300.200

0 references

D12.776.467.942.200.910

0 references

D12.776.467.942.300.200

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference