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GATA binding protein 1 (Q5512896)

From Wikidata
mammalian protein found in Homo sapiens
  • NF-E1 DNA-binding protein
  • GATA1
  • transcription factor GATA1
  • erythroid transcription factor 1
  • GATA-binding factor 1
  • nuclear factor, erythroid 1
  • GF-1
  • GATA-1
  • Eryf1
  • erythroid transcription factor
  • globin transcription factor 1
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Language Label Description Also known as
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No label defined
    English
    GATA binding protein 1
    mammalian protein found in Homo sapiens
    • NF-E1 DNA-binding protein
    • GATA1
    • transcription factor GATA1
    • erythroid transcription factor 1
    • GATA-binding factor 1
    • nuclear factor, erythroid 1
    • GF-1
    • GATA-1
    • Eryf1
    • erythroid transcription factor
    • globin transcription factor 1

    Statements

    molecular function
    DNA binding
    determination method or standard
    IEA
    IDA
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Knockdown of ZNF268, which Is Transcriptionally Downregulated by GATA-1, Promotes Proliferation of K562 Cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A novel erythroid differentiation related gene EDRF1 upregulating globin gene expression in HEL cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IPI
    7 references
    retrieved
    8 April 2019
    stated in
    Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CCAR1/CoCoA pair‐mediated recruitment of the Mediator defines a novel pathway for GATA1 function
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IPI
    cell component
    nucleus
    determination method or standard
    IEA
    IDA
    6 references
    retrieved
    5 June 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    5 June 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    5 June 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    5 June 2018
    stated in
    Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    5 June 2018
    stated in
    Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    5 June 2018
    stated in
    Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    nucleus
    determination method or standard
    IBA
    IDA
    IEA
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15976
    determination method or standard
    IBA
    biological process
    platelet formation
    determination method or standard
    IBA
    IEA
    IMP
    5 references
    retrieved
    1 January 2018
    stated in
    Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    X-linked thrombocytopenia caused by a novel mutation of GATA-1
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IBA
    positive regulation of transcription by RNA polymerase II
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    5 references
    retrieved
    1 January 2018
    stated in
    Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1
    GOA
    curator
    UniProt
    UniProt protein ID
    P15976
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GATA-1 forms distinct activating and repressive complexes in erythroid cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P15976&geneProductId=UniProtKB:P15976
    determination method or standard
    IBA
    Gene Atlas image
    PBB GE GATA1 210446 at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D050982
    subject named as
    GATA1 Transcription Factor
    0 references
     
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