PIN1, the cell cycle and cancer (Q53561253)

15 May 2018

title

PIN1, the cell cycle and cancer (English)

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15 May 2018

1

Elizabeth S Yeh

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15 May 2018

author name string

Anthony R Means

series ordinal

2

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15 May 2018

publication date

5 April 2007

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15 May 2018

language of work or name

English

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published in

Nature Reviews Cancer

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15 May 2018

volume

7

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15 May 2018

issue

5

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page(s)

381-388

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15 May 2018

publication type of scholarly work

review article

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Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

cites work

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Targeting carcinogenesis: a role for the prolyl isomerase Pin1?

31 March 2020

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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

31 March 2020

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A human peptidyl-prolyl isomerase essential for regulation of mitosis

31 March 2020

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Sequence and mutational analysis of ESS1, a gene essential for growth in Saccharomyces cerevisiae

31 March 2020

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The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1

31 March 2020

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The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

31 March 2020

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Pin1 acts catalytically to promote a conformational change in Cdc25.

31 March 2020

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Requirement of the prolyl isomerase Pin1 for the replication checkpoint

31 March 2020

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The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiae

31 March 2020

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Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest

31 March 2020

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The dodo gene family encodes a novel protein involved in signal transduction and protein folding

31 March 2020

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Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis

31 March 2020

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Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes

31 March 2020

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Pin1 regulates the timing of mammalian primordial germ cell proliferation

31 March 2020

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Spermatogonial depletion in adult Pin1-deficient mice

31 March 2020

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IGF‐1 induces Pin1 expression in promoting cell cycle S‐phase entry

31 March 2020

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PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans

31 March 2020

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PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells

31 March 2020

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The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability

31 March 2020

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Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC

31 March 2020

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Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

31 March 2020

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

31 March 2020

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Pin1 links the activities of c-Abl and p300 in regulating p73 function.

31 March 2020

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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

31 March 2020

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The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

31 March 2020

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Regulation of Raf-1 by direct feedback phosphorylation.

31 March 2020

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Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).

31 March 2020

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Prevalent overexpression of prolyl isomerase Pin1 in human cancers

31 March 2020

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Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction

31 March 2020

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Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression

31 March 2020

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Pin1 gene mutation is a rare event in gastric cancer

31 March 2020

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Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma

31 March 2020

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High Pin1 expression is associated with tumor progression in colorectal cancer

31 March 2020

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Expression of Pin1 and Ki67 in cervical cancer and their significance

31 March 2020

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Pinning down cell signaling, cancer and Alzheimer's disease

31 March 2020

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Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics

31 March 2020

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Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression.

31 March 2020

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Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer

31 March 2020

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Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer

31 March 2020

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An immunohistochemical scoring system of prolyl isomerase Pin1 for predicting relapse of prostate carcinoma after radical prostatectomy

31 March 2020

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Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

31 March 2020

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The prolyl isomerase Pin1 in breast development and cancer

31 March 2020

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Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms

31 March 2020

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Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

31 March 2020

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Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer

31 March 2020

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Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells

31 March 2020

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Deregulation of cyclin E in human cells interferes with prereplication complex assembly

31 March 2020

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Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

31 March 2020

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Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1.

31 March 2020

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Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

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Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

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Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression

31 March 2020

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Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1

31 March 2020

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Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects

31 March 2020

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A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice

31 March 2020

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TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

31 March 2020

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TGFbeta signaling in growth control, cancer, and heritable disorders

31 March 2020

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

31 March 2020

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Netrin-1 controls colorectal tumorigenesis by regulating apoptosis

31 March 2020

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PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma

31 March 2020

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PIN1 expression contributes to hepatic carcinogenesis.

31 March 2020

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High rates of loss of heterozygosity on chromosome 19p13 in human breast cancer

31 March 2020

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Incidence of chromosomal imbalances in advanced colorectal carcinomas and their metastases

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Chromosome abnormalities in oral squamous cell carcinomas.

31 March 2020

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19p Deletion in Recurring Leiomyosarcoma Lesions from the Same Patient

31 March 2020

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Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone

31 March 2020

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Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription

31 March 2020

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Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation

31 March 2020

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Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries

31 March 2020

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Conformationally locked isostere of phosphoSer-cis-Pro inhibits Pin1 23-fold better than phosphoSer-trans-Pro isostere

31 March 2020

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Vanishingly low levels of Ess1 prolyl-isomerase activity are sufficient for growth in Saccharomyces cerevisiae

31 March 2020

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Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

31 March 2020

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Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions

31 March 2020

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Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients

31 March 2020

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Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells

31 March 2020

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Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage

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Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint

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Proteasomal degradation of human peptidyl prolyl isomerase pin1-pointing phospho Bcl2 toward dephosphorylation

31 March 2020

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Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery

31 March 2020

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The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77 retinoic acid receptor alpha stability

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2107

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15 May 2018

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15 May 2018