Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin (Q52538423)

2 May 2018

title

Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin (English)

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2 May 2018

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Kawahara K

1

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2 May 2018

Morishita T

2

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2 May 2018

Nakamura T

3

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2 May 2018

Hamada F

4

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Toyoshima K

5

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2 May 2018

Akiyama T

6

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2 May 2018

publication date

1 March 2000

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2 May 2018

Journal of Biological Chemistry

language of work or name

English

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published in

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2 May 2018

volume

275

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2 May 2018

issue

12

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2 May 2018

page(s)

8369-8374

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2 May 2018

The adenomatous polyposis coli (APC) tumor suppressor

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Lessons from hereditary colorectal cancer

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Apoptosis and APC in colorectal tumorigenesis

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The APC gene product in normal and tumor cells

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The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

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The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells

21 January 2018

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Association of the APC gene product with beta-catenin

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Association of the APC tumor suppressor protein with catenins

21 January 2018

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Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein

21 January 2018

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Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

21 January 2018

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21 January 2018

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Signal transduction through beta-catenin and specification of cell fate during embryogenesis

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Wnt signaling: a common theme in animal development

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

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β-catenin is a target for the ubiquitin–proteasome pathway

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Functional interaction of beta-catenin with the transcription factor LEF-1

21 January 2018

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Nuclear localization of beta-catenin by interaction with transcription factor LEF-1

21 January 2018

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XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

21 January 2018

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

21 January 2018

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Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

21 January 2018

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

21 January 2018

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Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

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Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

21 January 2018

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Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level

21 January 2018

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Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

21 January 2018

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Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

21 January 2018

1 reference

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Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus Embryos

21 January 2018

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

21 January 2018

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Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

21 January 2018

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RGS proteins and signaling by heterotrimeric G proteins

21 January 2018

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GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain

21 January 2018

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RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits

21 January 2018

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Identification of c- MYC as a Target of the APC Pathway

21 January 2018

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Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.275.12.8369

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2 May 2018

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2 May 2018