opioid receptor mu 1 (Q5123372)

http://www.ebi.ac.uk/interpro/protein/P35372

G protein-coupled recepteishon

1 reference

Transporter Classification Database ID

9.A.14.13.18

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

morphine receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

neuropeptide binding

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

1 reference

24 April 2018

filamin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

protein binding

6 references

8 April 2019

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

Interaction Between the μ Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

MOR Is Not Enough: Identification of Novel mu-Opioid Receptor Interacting Proteins Using Traditional and Modified Membrane Yeast Two-Hybrid Screens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

Regulation of mu opioid receptor internalization by the scaffold protein RanBPM

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

G-protein alpha-subunit binding

1 reference

16 July 2018

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

protein C-terminus binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

protein domain specific binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

G-protein alpha-subunit binding

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

beta-endorphin receptor activity

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

peptide binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

cell component

postsynapse

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

Golgi apparatus

1 reference

8 April 2019

Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

focal adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

integral component of plasma membrane

1 reference

16 July 2018

Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

dendrite membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

endoplasmic reticulum

1 reference

8 April 2019

Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

neuron projection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

1 reference

16 July 2018

membrane raft

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

sarcolemma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

dendrite cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

4 references

8 April 2019

8 April 2019

Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

dendrite

ISS

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

1 reference

8 April 2019

spine apparatus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

integral component of postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

positive regulation of appetite

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

adenylate cyclase-activating dopamine receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

sensory perception

NAS

1 reference

8 April 2019

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

negative regulation of cAMP-mediated signaling

NAS

1 reference

24 April 2018

A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

regulation of sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

eating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

locomotory behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

estrous cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

positive regulation of cytosolic calcium ion concentration

1 reference

24 April 2018

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

positive regulation of nitric oxide biosynthetic process

1 reference

24 April 2018

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

negative regulation of Wnt protein secretion

1 reference

8 April 2019

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

wound healing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

acute inflammatory response to antigenic stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

positive regulation of cAMP-mediated signaling

1 reference

24 April 2018

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

response to morphine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

negative regulation of nitric oxide biosynthetic process

1 reference

24 April 2018

A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

calcium ion transmembrane transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

excitatory postsynaptic potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

behavioral response to ethanol

1 reference

8 April 2019

Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

response to food

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

sensory perception of pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

response to radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

response to growth factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

1 reference

8 April 2019

negative regulation of cell population proliferation

1 reference

8 April 2019

Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

negative regulation of cytosolic calcium ion concentration

1 reference

24 April 2018

A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

adenylate cyclase-inhibiting opioid receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

cellular response to morphine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

1 reference

16 July 2018

chemical synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

1 reference

16 July 2018

neuropeptide signaling pathway

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35372&geneProductId=UniProtKB:P35372

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

1 reference

8 April 2019

regulation of cellular response to stress

1 reference

8 April 2019

Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

neuropeptide signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

G protein-coupled opioid receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

cellular response to morphine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35372

physically interacts with

1 reference

8866

17 August 2016

1 reference

7691

17 August 2016

1 reference

7081

17 August 2016

1 reference

7082

17 August 2016

1 reference

7595

17 August 2016

1 reference

7215

17 August 2016

1 reference

5458

17 August 2016

1 reference

1663

17 August 2016

1 reference

7221

17 August 2016

1 reference

7477

17 August 2016

1 reference

1673

17 August 2016

1 reference

1607

17 August 2016

1 reference

1647

17 August 2016

1 reference

1616

17 August 2016

1 reference

1623

17 August 2016

1 reference

1624

17 August 2016

1 reference

1626

17 August 2016

1 reference

1605

17 August 2016

1 reference

1627

17 August 2016

1 reference

3534

17 August 2016

1 reference

1670

17 August 2016

1 reference

7591

17 August 2016

1 reference

1606

17 August 2016

1 reference

7471

17 August 2016

1 reference

1617

17 August 2016

1 reference

7209

17 August 2016

1 reference

7563

17 August 2016

1 reference

1628

17 August 2016

1 reference

1629

17 August 2016

1 reference

1638

17 August 2016

1 reference

1639

17 August 2016

1 reference

1640

17 August 2016

1 reference

1641

17 August 2016

1 reference

1633

English

17 August 2016

dezocine

Partial agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1685

butorphanol

Partial agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL33986

naloxegol

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2219418

oliceridine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2443262

codeine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL485

alfentanil

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL634

(RS)-methadone

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL651

cebranopadol

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2364605

eluxadoline

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2159122

dextropropoxyphene

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1213351

bevenopran

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3039511

L-morphan

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL592

methadone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200825

tramadol (not stereospecific)

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1237044

naltrexone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201149

fentanyl citrate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL688

hydromorphone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1237055

loperamide hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1707

nalbuphine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201132

oxycodone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200890

propoxyphene hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1237104

naloxone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1718

remifentanil hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201120

Gene Atlas image

PBB GE OPRM1 211359 s at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P35372

1 reference

GPCR, rhodopsin-like, 7TM

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35372

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

Transporter Classification Database ID

9.A.14.13.18

2 references

Transporter Classification database

13 March 2020

Transporter Classification database