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Caspase 8 (Q5049059)

From Wikidata
mammalian protein found in Homo sapiens
  • FADD-like ICE
  • caspase-8
  • MORT1-associated ced-3 homolog
  • caspase 8, apoptosis-related cysteine peptidase
  • FLICE
  • apoptotic cysteine protease
  • CASP8
  • caspase 8, apoptosis-related cysteine protease
  • MACH-alpha-1/2/3 protein
  • MACH-beta-1/2/3/4 protein
  • CAP4
  • FADD-homologous ICE/CED-3-like protease
  • MACH
  • apoptotic protease Mch-5
  • ICE-like apoptotic protease 5
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No label defined
    English
    Caspase 8
    mammalian protein found in Homo sapiens
    • FADD-like ICE
    • caspase-8
    • MORT1-associated ced-3 homolog
    • caspase 8, apoptosis-related cysteine peptidase
    • FLICE
    • apoptotic cysteine protease
    • CASP8
    • caspase 8, apoptosis-related cysteine protease
    • MACH-alpha-1/2/3 protein
    • MACH-beta-1/2/3/4 protein
    • CAP4
    • FADD-homologous ICE/CED-3-like protease
    • MACH
    • apoptotic protease Mch-5
    • ICE-like apoptotic protease 5

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    51 references
    retrieved
    9 May 2019
    stated in
    Calcium binding of ARC mediates regulation of caspase 8 and cell death
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14790
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14790
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14790
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14790
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Casper is a FADD- and caspase-related inducer of apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14790
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14790
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14790
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
    GOA
    curator
    UniProt
    UniProt protein ID
    Q14790
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Involvement of caspase 8 and c-FLIPL in the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A type III effector antagonizes death receptor signalling during bacterial gut infection
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Yes and PI3K bind CD95 to signal invasion of glioblastoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The role of receptor internalization in CD95 signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    TNF-alpha induces two distinct caspase-8 activation pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
    determination method or standard
    IPI
    cell component
    biological process
    Gene Atlas image
    PBB GE CASP8 213373 s at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    RefSeq protein ID
    Ensembl protein ID
    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q5049059&oldid=2383224410"