Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. (Q50355391)

6 March 2018

title

Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. (English)

1 reference

6 March 2018

author

Marka van Blitterswijk

8

1 reference

6 March 2018

Leonard Petrucelli

35

Leonard Petrucelli

1 reference

6 March 2018

Aliesha Garrett

15

0 references

Julien Couthouis

Julien Couthouis

10

0 references

Mercedes Prudencio

Mercedes Prudencio

7

0 references

Rosa Rademakers

19

Rosa Rademakers

1 reference

6 March 2018

24

David S Knopman

1 reference

6 March 2018

Bradley F Boeve

26

Bradley F Boeve

1 reference

6 March 2018

Ronald C. Petersen

25

Ronald C Petersen

1 reference

6 March 2018

Neill R Graff-Radford

21

Neill R Graff-Radford

1 reference

6 March 2018

Keith A Josephs

22

Keith A Josephs

1 reference

6 March 2018

Dennis W. Dickson

30

Dennis W Dickson

1 reference

6 March 2018

Joseph E Parisi

23

Joseph E Parisi

1 reference

6 March 2018

Kevin B Boylan

20

Kevin Boylan

1 reference

6 March 2018

Tania F Gendron

6

Tania F Gendron

1 reference

6 March 2018

Jeannie Chew

14

Jeannie Chew

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6 March 2018

Karen Jansen-West

17

Karen Jansen-West

1 reference

6 March 2018

Lillian M Daughrity

13

Lillian Daughrity

1 reference

6 March 2018

Casey N Cook

5

Casey N Cook

1 reference

6 March 2018

Yari Carlomagno

2

Yari Carlomagno

1 reference

6 March 2018

Aaron D Gitler

36

Aaron D Gitler

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6 March 2018

author name string

Nicholas J Kramer

1

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6 March 2018

Yong-Jie Zhang

3

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6 March 2018

Sandra Almeida

4

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6 March 2018

Veronique Belzil

9

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6 March 2018

Joseph West Paul

11

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6 March 2018

Lindsey D Goodman

12

1 reference

6 March 2018

Luc Pregent

16

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6 March 2018

Lilia J Tabassian

18

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6 March 2018

Ning Deng

27

1 reference

6 March 2018

Yanan Feng

28

1 reference

6 March 2018

Tzu-Hao Cheng

29

1 reference

6 March 2018

Stanley N Cohen

31

1 reference

6 March 2018

Nancy M Bonini

32

1 reference

6 March 2018

Christopher D Link

33

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6 March 2018

Fen-Biao Gao

34

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6 March 2018

language of work or name

English

0 references

publication date

1 August 2016

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6 March 2018

published in

Science

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6 March 2018

volume

353

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6 March 2018

page(s)

708-712

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6 March 2018

issue

6300

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6 March 2018

GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function

cites work

1 reference

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Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72.

22 May 2018

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Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS.

22 May 2018

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Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers

22 May 2018

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GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

22 May 2018

1 reference

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Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS.

22 May 2018

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Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

22 May 2018

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Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown

22 May 2018

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Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death

22 May 2018

1 reference

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Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.

22 May 2018

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C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

22 May 2018

1 reference

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C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Mechanisms of toxicity in C9FTLD/ALS.

22 May 2018

1 reference

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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

22 May 2018

1 reference

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Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic

22 May 2018

1 reference

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RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

22 May 2018

1 reference

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Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

22 May 2018

1 reference

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Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion

22 May 2018

1 reference

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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention

22 May 2018

1 reference

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Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

22 May 2018

1 reference

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Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study

22 May 2018

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Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

22 May 2018

1 reference

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Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits

22 May 2018

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Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

22 May 2018

1 reference

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Spt4 is selectively required for transcription of extended trinucleotide repeats

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

22 May 2018

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Dramatically improved RNA in situ hybridization signals using LNA-modified probes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Molecular evidence for a positive role of Spt4 in transcription elongation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Mating type switching in yeast controlled by asymmetric localization of ASH1 mRNA.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

The genetics of Caenorhabditis elegans

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823025

14 August 2018

Identifiers

DOI

10.1126/SCIENCE.AAF7791

1 reference

6 March 2018

0 references

1 reference

6 March 2018

PubMed ID

27516603

1 reference

6 March 2018