The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications. (Q49611544)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29177281%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

title

The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications (English)

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4 April 2020

3

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4 April 2020

John M Kelly

5

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4 April 2020

Thorfinnur Gunnlaugsson

6

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4 April 2020

Fergus E Poynton

1

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4 April 2020

author name string

Sandra A Bright

2

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4 April 2020

D Clive Williams

4

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4 April 2020

publication date

1 December 2017

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4 April 2020

published in

Chemical Society Reviews

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4 April 2020

volume

46

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4 April 2020

page(s)

7706-7756

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4 April 2020

issue

24

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Functional ruthenium(II)- and iridium(III)-containing polymers for potential electro-optical applications

4 April 2020

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21 January 2018

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Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(ii) polypyridyl complex†Electronic supplementary information (ESI) available: Experimental details, characterization of 2 and Fig. S1-S6. See DOI: [...]

21 January 2018

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RNA and DNA binding of inert oligonuclear ruthenium(II) complexes in live eukaryotic cells

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Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells

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Tumor hypoxia in cancer therapy

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Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)(dppz)] light-switch compound in solution and when bound to DNA

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Enantiomeric Conformation Controls Rate and Yield of Photoinduced Electron Transfer in DNA Sensitized by Ru(II) Dipyridophenazine Complexes.

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Effects of chirality on the intracellular localization of binuclear ruthenium(II) polypyridyl complexes

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Chiral ruthenium(II) polypyridyl complexes: stabilization of g-quadruplex DNA, inhibition of telomerase activity and cellular uptake

21 January 2018

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Bioimaging: second window for in vivo imaging

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Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA.

21 January 2018

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Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy.

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Tetranuclear ruthenium(II) complexes with oligo-oxyethylene linkers as one- and two-photon luminescent tracking non-viral gene vectors.

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Lipophilic tetranuclear ruthenium(II) complexes as two-photon luminescent tracking non-viral gene vectors

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Uniting Ruthenium(II) and Platinum(II) Polypyridine Centers in Heteropolymetallic Complexes Giving Strong Two-Photon Absorption

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Evaluation of the Medicinal Potential of Two Ruthenium(II) Polypyridine Complexes as One- and Two-Photon Photodynamic Therapy Photosensitizers.

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Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy?

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Crossfire for Two-Photon Photodynamic Therapy with Fluorinated Ruthenium (II) Photosensitizers.

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Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo.

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3D cell culture systems modeling tumor growth determinants in cancer target discovery

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Molecular mechanisms of resistance and toxicity associated with platinating agents

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Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

21 January 2018

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Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

21 January 2018

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Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

21 January 2018

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Ruthenium complexes can target determinants of tumour malignancy

21 January 2018

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In vitro transcription inhibition by ruthenium(II) polypyridyl complexes with electropositive ancillary ligands

21 January 2018

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Nuclear permeable ruthenium(II) β-carboline complexes induce autophagy to antagonize mitochondrial-mediated apoptosis

21 January 2018

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Chemotherapeutic approaches for targeting cell death pathways

21 January 2018

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A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP.

21 January 2018

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Mitochondria are the primary target in the induction of apoptosis by chiral ruthenium(II) polypyridyl complexes in cancer cells

21 January 2018

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Ruthenium(II) polypyridyl complexes induce BEL-7402 cell apoptosis by ROS-mediated mitochondrial pathway

21 January 2018

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Ruthenium polypyridyl complexes that induce mitochondria-mediated apoptosis in cancer cells

21 January 2018

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Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes.

21 January 2018

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Ruthenium(II) complexes: DNA-binding, cytotoxicity, apoptosis, cellular localization, cell cycle arrest, reactive oxygen species, mitochondrial membrane potential and western blot analysis

21 January 2018

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Design, synthesis and evaluation of anticancer activity of ruthenium (II) polypyridyl complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Know your target, know your molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Principles of early drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Prediction of individual response to anticancer therapy: historical and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Structure-based strategies for drug design and discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Quantitative structure-activity relationship methods: perspectives on drug discovery and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The practice of structure activity relationships (SAR) in toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Bis(dipyridophenazine)(2-(2'-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) hexafluorophosphate: a lesson in stubbornness

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Synthesis, characterization and antitumor activity of a series of polypyridyl complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Synthesis, antitumor activity and structure-activity relationships of a series of Ru(II) complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

DNA Interaction and Cytotoxicity of Cyclometalated Ruthenium(II) Complexes as Potential Anticancer Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium (II)-derived organometallic compounds induce cytostatic and cytotoxic effects on mammalian cancer cell lines through p53-dependent and p53-independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Chiral ruthenium(II) complexes with phenolic hydroxyl groups as dual poisons of topoisomerases I and IIα.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Targeting topoisomerase II with the chiral DNA-intercalating ruthenium(II) polypyridyl complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

In vitro anticancer activity of cis-diammineplatinum(II) complexes with β-diketonate leaving group ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium polypyridyl complexes and their modes of interaction with DNA: is there a correlation between these interactions and the antitumor activity of the compounds?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

DNA binding, cytotoxicity, and apoptotic-inducing activity of ruthenium(II) polypyridyl complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cellular uptake, cytotoxicity, apoptosis, DNA-binding, photocleavage and molecular docking studies of ruthenium(II) polypyridyl complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Meta-analysis of cellular toxicity for cadmium-containing quantum dots

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The role of quantitative structure--activity relationships (QSAR) in biomolecular discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Approaches to Measure Chemical Similarity– a Review

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Partitioning and lipophilicity in quantitative structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cytotoxicity in cultured mammalian cells is a function of the method used to estimate it.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A practical note on the use of cytotoxicity assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium dihydroxybipyridine complexes are tumor activated prodrugs due to low pH and blue light induced ligand release

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The clinical relevance of cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Biological activity of complex ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Functionalized Multiwalled Carbon Nanotubes as Carriers of Ruthenium Complexes to Antagonize Cancer Multidrug Resistance and Radioresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A ruthenium(II) complex inhibits tumor growth in vivo with fewer side-effects compared with cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Regression of lung cancer by hypoxia-sensitizing ruthenium polypyridyl complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The history of photodetection and photodynamic therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The physics, biophysics and technology of photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photodynamic therapy for treatment of solid tumors--potential and technical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Combination of Ru(ii) complexes and light: new frontiers in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Chemical Synthesis and Medicinal Applications of Glycoporphyrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photodynamic therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Differential cell death response to photodynamic therapy is dependent on dose and cell type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cell death pathways in photodynamic therapy of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ru(II) complexes of new tridentate ligands: unexpected high yield of sensitized 1O2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Exploitation of long-lived 3IL excited states for metal-organic photodynamic therapy: verification in a metastatic melanoma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Singlet oxygen-mediated damage to proteins and its consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Singlet oxygen in a cell: spatially dependent lifetimes and quenching rate constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Organometallic Ru(II) Photosensitizers Derived from π-Expansive Cyclometalating Ligands: Surprising Theranostic PDT Effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photodynamic inactivation of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with Ru(II)-based type I/type II photosensitizers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A GSH-activatable ruthenium(ii)-azo photosensitizer for two-photon photodynamic therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Simultaneous two-photon excitation of photofrin in relation to photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Signaling pathways in cell death and survival after photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Targeting lipophilic cations to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Quantitative in vitro demonstration of two-photon photodynamic therapy using photofrin and visudyne

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Two-photon excitation nanoparticles for photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Rapid photolytic release of adenosine 5'-triphosphate from a protected analog: utilization by the sodium:potassium pump of human red blood cell ghosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Strained ruthenium complexes are potent light-activated anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Strained ruthenium metal-organic dyads as photocisplatin agents with dual action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

To cage or to be caged? The cytotoxic species in ruthenium-based photoactivated chemotherapy is not always the metal

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cytotoxicity of cyclometallated ruthenium complexes: the role of ligand exchange on the activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Development and application of bond cleavage reactions in bioorthogonal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Biologically active molecules with a "light switch".

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Caged compounds: photorelease technology for control of cellular chemistry and physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Inhibition of cathepsin activity in a cell-based assay by a light-activated ruthenium compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Light activation of a cysteine protease inhibitor: caging of a peptidomimetic nitrile with Ru(II)(bpy)2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A caged nicotine with nanosecond range kinetics and visible light sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium(II) bipyridyl complexes as photolabile caging groups for amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

RuBi-Glutamate: Two-Photon and Visible-Light Photoactivation of Neurons and Dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A new inorganic photolabile protecting group for highly efficient visible light GABA uncaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A ruthenium-rhodamine complex as an activatable fluorescent probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cellular toxicity induced by the photorelease of a caged bioactive molecule: design of a potential dual-action Ru(II) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Effect of dye aggregation on triarylmethane-mediated photoinduced damage of hexokinase and DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Oxygen independent DNA interstrand cross-link formation by a nucleotide radical

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Targeting hypoxia in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium oligonucleotides, targeting HPV16 E6 oncogene, inhibit the growth of cervical cancer cells under illumination by a mechanism involving p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

ps-TRIR covers all the bases--recent advances in the use of transient IR for the detection of short-lived species in nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photochemically active DNA-intercalating ruthenium and related complexes - insights by combining crystallography and transient spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru(bpy)2dppz](2.).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Overcoming the Achilles' heel of photodynamic therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Nanoscintillator-mediated X-ray inducible photodynamic therapy for in vivo cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The concurrent chemoradiation paradigm--general principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Rational Design of Ruthenium Complexes Containing 2,6-Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Effect of radiation on cytotoxicity, apoptosis and cell cycle arrest of human osteosarcoma MG-63 induced by a ruthenium(II) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The origin and meaning of the term "photodynamic" (as used in "photodynamic therapy", for example).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photodynamic therapy: a new concept in medical treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Oligonucleotide Therapies: The Past and the Present

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Targeting of photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene using oligonucleotide-conjugates containing [Ru(phen)3](2+)-like photosensitiser groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

[Ru(TAP)2(dppz)]2+: a DNA intercalating complex, which luminesces strongly in water and undergoes photo-induced proton-coupled electron transfer with guanosine-5'-monophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photoaddition of two guanine bases to single Ru-TAP complexes. Computational studies and ultrafast spectroscopies to elucidate the pH dependence of primary processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A ruthenocene-PNA bioconjugate--synthesis, characterization, cytotoxicity, and AAS-detected cellular uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Luminescent conjugates between dinuclear rhenium(I) complexes and peptide nucleic acids (PNA) for cell imaging and DNA targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Antitumor activity of a pyrrole-imidazole polyamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Transition metal derivatives of peptide nucleic acid (PNA) oligomers-synthesis, characterization, and DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Di-heterometalation of thiol-functionalized peptide nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

DTS-108, a novel peptidic prodrug of SN38: in vivo efficacy and toxicokinetic studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cell-penetrating peptides as delivery vehicles for biology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

RGD labeled Ru(II) polypyridyl conjugates for platelet integrin αIIbβ3 recognition and as reporters of integrin conformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Translocation mechanism(s) of cell-penetrating peptides: biophysical studies using artificial membrane bilayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cell-penetrating peptides: 20 years later, where do we stand?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Therapeutic applications of the cell-penetrating HIV-1 Tat peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A brief introduction to cell-penetrating peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cell-penetrating peptides: design, synthesis, and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Fluorescein redirects a ruthenium-octaarginine conjugate to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Targeting a ruthenium complex to the nucleus with short peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Peptide-bridged dinuclear Ru(II) complex for mitochondrial targeted monitoring of dynamic changes to oxygen concentration and ROS generation in live mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Precision targeted ruthenium(ii) luminophores; highly effective probes for cell imaging by stimulated emission depletion (STED) microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Nuclear import of polypeptides, polynucleotides and supramolecular complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Beyond the signal sequence: protein routing in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Controlling subcellular delivery to optimize therapeutic effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Peptide directed transmembrane transport and nuclear localization of Ru(II) polypyridyl complexes in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Mitochondrial cristae revealed with focused light

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The spacer arm length in cell-penetrating peptides influences chitosan/siRNA nanoparticle delivery for pulmonary inflammation treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cellular uptake and cytotoxicity of drug-peptide conjugates regulated by conjugation site

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Sugar-selective enrichment of a D-glucose-substituted ruthenium bipyridyl complex inside HepG2 cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

New Luminescent Polynuclear Metal Complexes with Anticancer Properties: Toward Structure-Activity Relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A review of glycosylated carriers for drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

d- Versus l-Glucose Conjugation: Mitochondrial Targeting of a Light-Activated Dual-Mode-of-Action Ruthenium-Based Anticancer Prodrug

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ruthenium polypyridyl squalene derivative: a novel self-assembling lipophilic probe for cellular imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Luminescent biological probes derived from ruthenium(II) estradiol polypyridine complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Chemical Swarming: Depending on Concentration, an Amphiphilic Ruthenium Polypyridyl Complex Induces Cell Death via Two Different Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Histone-deacetylase-targeted fluorescent ruthenium(II) polypyridyl complexes as potent anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Discovery and development of SAHA as an anticancer agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Vorinostat in solid and hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Receptor tyrosine kinase signalling as a target for cancer intervention strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Responsive and mitochondria-specific ruthenium(II) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Two-photon induced luminescence, singlet oxygen generation, cellular uptake and photocytotoxic properties of amphiphilic Ru(II) polypyridyl-porphyrin conjugates as potential bifunctional photodynamic therapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(II)-polypyridyl conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Highly effective DNA photocleavage by novel "rigid" Ru(bpy)(3)-4-nitro- and -4-amino-1,8-naphthalimide conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Therapeutic nanoparticles for drug delivery in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Ru(II)-polypyridyl surface functionalised gold nanoparticles as DNA targeting supramolecular structures and luminescent cellular imaging agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

High coating of Ru(II) complexes on gold nanoparticles for single particle luminescence imaging in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Highly luminescent gold nanoparticles: effect of ruthenium distance for nanoprobes with enhanced lifetimes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Functional nanomaterials for phototherapies of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Bifunctional polypyridyl-Ru(II) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Photoexpulsion of surface-grafted ruthenium complexes and subsequent release of cytotoxic cargos to cancer cells from mesoporous silica nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Rational design of cancer-targeted selenium nanoparticles to antagonize multidrug resistance in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The effects of luminescent ruthenium(II) polypyridyl functionalized selenium nanoparticles on bFGF-induced angiogenesis and AKT/ERK signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized ruthenium-thiol protected selenium nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Phosphorescent nanoparticles for quantitative measurements of oxygen profiles in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Noncovalent Ruthenium(II) Complexes-Single-Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Mitigating risk in academic preclinical drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Bringing together the academic drug discovery community

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The importance of new companies for drug discovery: origins of a decade of new drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The Role of Public-Sector Research in the Discovery of Drugs and Vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Believe it or not: how much can we rely on published data on potential drug targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The Economics of Reproducibility in Preclinical Research

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

1,500 scientists lift the lid on reproducibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Drug discoverers chart path to tackling data irreproducibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Managing risks in drug discovery: reproducibility of published findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Why and how have drug discovery strategies in pharma changed? What are the new mindsets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Tackling reproducibility in academic preclinical drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Drug development: Raise standards for preclinical cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Reproducibility: Respect your cells!

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Why current publication practices may distort science

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

False leukemia–lymphoma cell lines: an update on over 500 cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Origin of the U87MG glioma cell line: Good news and bad news

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Drug Discovery in Academia- the third way?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

The emerging role of academia in commercializing innovation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

An incentive-based approach for improving data reproducibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Reproducibility2020: Progress and priorities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Effect of Inorganic Complex Ions on Transmission at a Neuromuscular Junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Marked Improvement in Photoinduced Cell Death by a New Tris-heteroleptic Complex with Dual Action: Singlet Oxygen Sensitization and Ligand Dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

DNA Intercalating RuIIPolypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Metal-containing peptide nucleic acid conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and 1 O 2 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7CS00680B

Know Thy Cells: Improving Biomedical Research Reproducibility

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCITRANSLMED.AAC7112

[Ru(bpy)3]2+* and other remarkable metal-to-ligand charge transfer (MLCT) excited states

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC-CON-13-03-04

Identifiers

DOI

10.1039/C7CS00680B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29177281%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

1 reference