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BCL2 antagonist/killer 1 (Q4875407)

From Wikidata
mammalian protein found in Homo sapiens
  • apoptosis regulator BAK
  • bcl-2-like protein 7
  • pro-apoptotic protein BAK
  • BCL2-like 7 protein
  • BAK1
  • bcl-2 homologous antagonist/killer
  • bcl2-L-7
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    English
    BCL2 antagonist/killer 1
    mammalian protein found in Homo sapiens
    • apoptosis regulator BAK
    • bcl-2-like protein 7
    • pro-apoptotic protein BAK
    • BCL2-like 7 protein
    • BAK1
    • bcl-2 homologous antagonist/killer
    • bcl2-L-7

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    31 references
    retrieved
    8 April 2019
    stated in
    A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16611
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16611
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BID-induced structural changes in BAK promote apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An empirical framework for binary interactome mapping
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Towards a proteome-scale map of the human protein–protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    High-throughput methods to detect dimerization of Bcl-2 family proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human Bop is a novel BH3-only member of the Bcl-2 protein family
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Heterodimerization of BAK and MCL-1 activated by detergent micelles
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    identical protein binding
    determination method or standard
    IPI
    5 references
    retrieved
    8 April 2019
    stated in
    Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BH3 domains other than Bim and Bid can directly activate Bax/Bak
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
    determination method or standard
    IPI
    cell component
    biological process
    Gene Atlas image
    PBB GE BAK1 203728 at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D050998
    subject named as
    bcl-2 Homologous Antagonist-Killer Protein
    0 references
    PDB structure ID
     
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