B-Raf proto-oncogene, serine/threonine kinase (Q21109218)

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mammalian protein found in Homo sapiens
  • 94 kDa B-raf protein
  • v-raf murine sarcoma viral oncogene homolog B1
  • BRAF
  • B-Raf proto-oncogene serine/threonine-protein kinase (p94)
  • serine/threonine-protein kinase B-raf
  • murine sarcoma viral (v-raf) oncogene homolog B1
  • v-raf murine sarcoma viral oncogene homolog B
  • proto-oncogene B-Raf
  • B-Raf serine/threonine-protein
  • p94
  • Proto-Oncogene Proteins B-raf
edit
Language Label Description Also known as
English
B-Raf proto-oncogene, serine/threonine kinase
mammalian protein found in Homo sapiens
  • 94 kDa B-raf protein
  • v-raf murine sarcoma viral oncogene homolog B1
  • BRAF
  • B-Raf proto-oncogene serine/threonine-protein kinase (p94)
  • serine/threonine-protein kinase B-raf
  • murine sarcoma viral (v-raf) oncogene homolog B1
  • v-raf murine sarcoma viral oncogene homolog B
  • proto-oncogene B-Raf
  • B-Raf serine/threonine-protein
  • p94
  • Proto-Oncogene Proteins B-raf

Statements

molecular function
protein binding
determination method
IPI
30 references
retrieved
8 April 2019
stated in
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
GOA
curator
UniProt
UniProt protein ID
P15056
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
ERK and PDE4 cooperate to induce RAF isoform switching in melanoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
RAF inhibitors that evade paradoxical MAPK pathway activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
IQGAP1 modulates activation of B-Raf
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
IQGAP1 modulates activation of B-Raf
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
identical protein binding
determination method
IPI
6 references
retrieved
8 April 2019
stated in
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
A dimerization-dependent mechanism drives RAF catalytic activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
retrieved
8 April 2019
stated in
The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE BRAF 206044 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D048493
subject named as
Proto-Oncogene Proteins B-raf
0 references
PDB structure ID
 
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