Interaction interface of human flap endonuclease-1 with its DNA substrates (Q46782179)

25 December 2017

title

Interaction interface of human flap endonuclease-1 with its DNA substrates (English)

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25 December 2017

author name string

Junzhuan Qiu

1

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25 December 2017

Ren Liu

2

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25 December 2017

Brian R Chapados

3

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25 December 2017

Mark Sherman

4

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25 December 2017

John A Tainer

5

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25 December 2017

Binghui Shen

6

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25 December 2017

publication date

22 March 2004

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25 December 2017

Journal of Biological Chemistry

language of work or name

English

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number of pages

9

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based on heuristic

inferred from page(s)

published in

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25 December 2017

volume

279

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issue

23

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page(s)

24394-24402

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25 December 2017

Enzymatic completion of mammalian lagging-strand DNA replication

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Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.

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Mutator specificity and disease: looking over the FENce

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Novel function of Rad27 (FEN-1) in restricting short-sequence recombination

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Functional genomic analysis of apoptotic DNA degradation in C. elegans.

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Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair

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Essential amino acids for substrate binding and catalysis of human flap endonuclease 1

21 January 2018

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Flap endonuclease homologs in archaebacteria exist as independent proteins.

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Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair

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Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region

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Involvement of flap endonuclease 1 in base excision DNA repair.

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Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair

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A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease

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Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins

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Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity

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The crystal structure of flap endonuclease-1 from Methanococcus jannaschii

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Mechanism of tracking and cleavage of adduct-damaged DNA substrates by the mammalian 5'- to 3'-exonuclease/endonuclease RAD2 homologue 1 or flap endonuclease 1.

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The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.

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Human flap endonuclease-1: conformational change upon binding to the flap DNA substrate and location of the Mg2+ binding site

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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

21 January 2018

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Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination

21 January 2018

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Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshii

21 January 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

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Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.

21 January 2018

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Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG

21 January 2018

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Comparison of the 5' nuclease activities of taq DNA polymerase and its isolated nuclease domain

21 January 2018

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Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate

21 January 2018

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Calf 5' to 3' exo/endonuclease must slide from a 5' end of the substrate to perform structure-specific cleavage

21 January 2018

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The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites

21 January 2018

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Effect of flap modifications on human FEN1 cleavage

21 January 2018

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Modeling of Flap Endonuclease Interactions with DNA Substrate

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M401464200

1 reference

25 December 2017

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25 December 2017