Aldo-keto reductase family 1 member C4 (Q4634197)

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mammalian protein found in Homo sapiens

type I 3-alpha-hydroxysteroid dehydrogenase
HAKRA
1.1.1.225
aldo-keto reductase family 1 member C4
chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4
dihydrodiol dehydrogenase isozyme DD4
3-alpha-hydroxysteroid dehydrogenase type I
DD-4
CDR
3-alpha-HSD1
1.1.1.357
Chlordecone reductase
Dihydrodiol dehydrogenase 4
AKR1C4
DD4

Language	Label	Description	Also known as
English	Aldo-keto reductase family 1 member C4	mammalian protein found in Homo sapiens	type I 3-alpha-hydroxysteroid dehydrogenase HAKRA 1.1.1.225 aldo-keto reductase family 1 member C4 chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4 dihydrodiol dehydrogenase isozyme DD4 3-alpha-hydroxysteroid dehydrogenase type I DD-4 CDR 3-alpha-HSD1 1.1.1.357 Chlordecone reductase Dihydrodiol dehydrogenase 4 AKR1C4 DD4

Statements

1 reference

13 November 2019

UniProt protein ID

aldo/keto reductase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17516

NADP-dependent oxidoreductase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17516

NADP-dependent oxidoreductase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldo/keto reductase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

retinal dehydrogenase activity

determination method

1 reference

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

aldo-keto reductase (NADP) activity

determination method

1 reference

8 April 2019

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

bile acid transmembrane transporter activity

determination method

1 reference

8 April 2019

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

determination method

1 reference

8 April 2019

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

chlordecone reductase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

electron transfer activity

determination method

1 reference

8 April 2019

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

androsterone dehydrogenase activity

determination method

1 reference

31 October 2017

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17516&geneProductId=UniProtKB:P17516

determination method

alditol:NADP+ 1-oxidoreductase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

alcohol dehydrogenase (NADP+) activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

steroid dehydrogenase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

oxidoreductase activity

determination method

ketosteroid monooxygenase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17516&geneProductId=UniProtKB:P17516

determination method

extracellular exosome

determination method

1 reference

31 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17516&geneProductId=UniProtKB:P17516

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

biological process

cellular response to jasmonic acid stimulus

determination method

1 reference

8 April 2019

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

steroid metabolic process

determination method

1 reference

31 October 2017

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17516&geneProductId=UniProtKB:P17516

determination method

daunorubicin metabolic process

determination method

1 reference

31 October 2017

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17516&geneProductId=UniProtKB:P17516

determination method

doxorubicin metabolic process

determination method

1 reference

31 October 2017

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17516&geneProductId=UniProtKB:P17516

determination method

androgen metabolic process

determination method

1 reference

8 April 2019

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

retinoid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

bile acid and bile salt transport

determination method

1 reference

8 April 2019

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

bile acid biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

electron transport chain

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

prostaglandin metabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

progesterone metabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17516

determination method

EC enzyme number

1.1.1.225

1 reference

5 January 2016

http://www.uniprot.org/uniprot/P17516.txt?version=177

Gene Atlas image

PBB GE AKR1C4 210558 at fs.png
732 × 530; 11 KB

0 references

Aldo/keto reductase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17516

NADP-dependent oxidoreductase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17516

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000369814

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369814

ENSP00000263126

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000263126

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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