Dna2 helicase/nuclease causes replicative fork stalling and double-strand breaks in the ribosomal DNA of Saccharomyces cerevisiae (Q46123466)

19 December 2017

title

Dna2 helicase/nuclease causes replicative fork stalling and double-strand breaks in the ribosomal DNA of Saccharomyces cerevisiae (English)

1 reference

19 December 2017

main subject

Saccharomyces cerevisiae

1 reference

3

Laura L Mays Hoopes

1 reference

19 December 2017

author name string

Tao Weitao

series ordinal

1

1 reference

19 December 2017

Martin Budd

series ordinal

2

1 reference

19 December 2017

Judith L Campbell

series ordinal

4

1 reference

19 December 2017

publication date

9 April 2003

1 reference

19 December 2017

Journal of Biological Chemistry

language of work or name

English

0 references

published in

1 reference

19 December 2017

volume

278

1 reference

19 December 2017

issue

25

1 reference

19 December 2017

page(s)

22513-22522

1 reference

19 December 2017

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

The DNA replication checkpoint response stabilizes stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Positive torsional strain causes the formation of a four-way junction at replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Organization of replication of ribosomal DNA in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

A replication fork barrier at the 3' end of yeast ribosomal RNA genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Architecture of the replication fork stalled at the 3' end of yeast ribosomal genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Mutations in DNA replication genes reduce yeast life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

A yeast gene required for DNA replication encodes a protein with homology to DNA helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

DNA2 Encodes a DNA Helicase Essential for Replication of Eukaryotic Chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

The nuclease activity of the yeast DNA2 protein, which is related to the RecB-like nucleases, is essential in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Dna2 of Saccharomyces cerevisiae Possesses a Single-stranded DNA-specific Endonuclease Activity That Is Able to Act on Double-stranded DNA in the Presence of ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Tripartite structure of Saccharomyces cerevisiae Dna2 helicase/endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Characterization ofSaccharomyces cerevisiae dna2Mutants Suggests a Role for the Helicase Late in S Phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

The endonuclease activity of the yeast Dna2 enzyme is essential in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Mutational Analysis of the Structure and Localization of the Nucleolus in the Yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Complete deletion of yeast chromosomal rDNA repeats and integration of a new rDNA repeat: use of rDNA deletion strains for functional analysis of rDNA promoter elements in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

The localization of replication origins on ARS plasmids in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Cis-acting, recombination-stimulating activity in a fragment of the ribosomal DNA of S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Structure and function of the nontranscribed spacer regions of yeast rDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

The arrest of replication forks in the rDNA of yeast occurs independently of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Elimination of replication block protein Fob1 extends the life span of yeast mother cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Biochemical analyses of mutations in the HSV-1 helicase-primase that alter ATP hydrolysis, DNA unwinding, and coupling between hydrolysis and unwinding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Mutation of a Highly Conserved Arginine in Motif IV of Escherichia coli DNA Helicase II Results in an ATP-binding Defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Pif1p helicase, a catalytic inhibitor of telomerase in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Telomere length constancy during aging of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Extrachromosomal rDNA circles--a cause of aging in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Yeast RNA polymerase I enhancer is dispensable for transcription of the chromosomal rRNA gene and cell growth, and its apparent transcription enhancement from ectopic promoters requires Fob1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Paradigms and pitfalls of yeast longevity research

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

DNA double-strand breaks caused by replication arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Replication fork reversal in DNA polymerase III mutants of Escherichia coli: a role for the beta clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Rescue of stalled replication forks by RecG: simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Recombinational rescue of the stalled DNA replication fork: a model based on analysis of an Escherichia coli strain with a chromosome region difficult to replicate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Arrest of bacterial DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Termination of DNA replication of bacterial and plasmid chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Initiation and termination of DNA replication in human rRNA genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Replication fork barriers in the Xenopus rDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Replication fork collapse at replication terminator sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Replication forks pause at yeast centromeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

DNA replication forks pause at silent origins near the HML locus in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Sir2p suppresses recombination of replication forks stalled at the replication fork barrier of ribosomal DNA in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

An unusual form of transcriptional silencing in yeast ribosomal DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Coupling of DNA Helicase and Endonuclease Activities of Yeast Dna2 Facilitates Okazaki Fragment Processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Characterization of the Enzymatic Properties of the Yeast Dna2 Helicase/Endonuclease Suggests a New Model for Okazaki Fragment Processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

The in vivo replication origin of the yeast 2 microns plasmid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Initiation at closely spaced replication origins in a yeast chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

RuvAB acts at arrested replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Action of RuvAB at replication fork structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

DNA replication fork pause sites dependent on transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

Arrest of segregation leads to accumulation of highly intertwined catenated dimers: Dissection of the final stages of SV40 DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301610200

21 January 2018

Identifiers

DOI

10.1074/JBC.M301610200

1 reference

19 December 2017

1 reference

19 December 2017