TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest (Q42827040)

8 November 2017

TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest (English)

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8 November 2017

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Schneider L

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8 November 2017

Essmann F

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8 November 2017

Kletke A

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8 November 2017

Rio P

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8 November 2017

Hanenberg H

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8 November 2017

Schulze-Osthoff K

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8 November 2017

Nürnberg B

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8 November 2017

Piekorz RP

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8 November 2017

language of work or name

English

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publication date

25 June 2007

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8 November 2017

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8 November 2017

27

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8 November 2017

116-125

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8 November 2017

1

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210628

8 November 2017

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Are p27 and p21 cytoplasmic oncoproteins?

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Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis.

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Cytostatic activity of paclitaxel in coronary artery smooth muscle cells is mediated through transient mitotic arrest followed by permanent post-mitotic arrest: comparison with cancer cells

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Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

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TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly

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The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability

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New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

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Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis.

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The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells

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Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

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CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division

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Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy

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Microtubules as a target for anticancer drugs

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Aberrations of TACC1 and TACC3 are associated with ovarian cancer

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Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.

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Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest

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The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis

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Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle.

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Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon

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The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines

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Regulation of the G2/M transition by p53.

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Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

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7 January 2021

Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells

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7 January 2021

Expression of transforming acidic coiled-coil containing protein 3 is a novel independent prognostic marker in non-small cell lung cancer

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7 January 2021

Differential modulation of paclitaxel-mediated apoptosis by p21Waf1 and p27Kip1

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7 January 2021

p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation

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7 January 2021

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

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7 January 2021

TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210628

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Dimensions Publication ID

8 November 2017

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