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BCL2 apoptosis regulator (Q425201)

From Wikidata
mammalian protein found in Homo sapiens
  • protein phosphatase 1, regulatory subunit 50
  • B-cell CLL/lymphoma 2
  • apoptosis regulator Bcl-2
  • Bcl-2
  • BCL2
  • PPP1R50
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    English
    BCL2 apoptosis regulator
    mammalian protein found in Homo sapiens
    • protein phosphatase 1, regulatory subunit 50
    • B-cell CLL/lymphoma 2
    • apoptosis regulator Bcl-2
    • Bcl-2
    • BCL2
    • PPP1R50

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    63 references
    retrieved
    8 April 2019
    stated in
    PUMA induces the rapid apoptosis of colorectal cancer cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BAG-1 modulates the chaperone activity of Hsp70/Hsc70
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Noxa/Bcl-2 Protein Interactions Contribute to Bortezomib Resistance in Human Lymphoid Cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-G, a novel pro-apoptotic member of the Bcl-2 family
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 has a direct apoptogenic role at the mitochondria
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in Yeast
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Noxa/Bcl-2 Protein Interactions Contribute to Bortezomib Resistance in Human Lymphoid Cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The IKK complex contributes to the induction of autophagy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A short Nur77-derived peptide converts Bcl-2 from a protector to a killer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 has a direct apoptogenic role at the mitochondria
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IPI
    cell component
    biological process
    negative regulation of apoptotic process
    determination method or standard
    IDA
    IEA
    IGI
    IMP
    TAS
    18 references
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    TAS
    retrieved
    16 July 2018
    stated in
    BCL-2 Is a Downstream Target of ATF5 That Mediates the Prosurvival Function of ATF5 in a Cell Type-dependent Manner
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in Yeast
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IGI
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    Regulation of acidification and apoptosis by SHP-1 and Bcl-2
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Proapoptotic BAX and BAK control multiple initiator caspases
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Inhibition of Bax channel-forming activity by Bcl-2
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    negative regulation of apoptotic process
    determination method or standard
    IBA
    IDA
    IEA
    IGI
    IMP
    TAS
    20 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    BCL-2 Is a Downstream Target of ATF5 That Mediates the Prosurvival Function of ATF5 in a Cell Type-dependent Manner
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in Yeast
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Regulation of acidification and apoptosis by SHP-1 and Bcl-2
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore
    GOA
    curator
    UniProt
    UniProt protein ID
    P10415
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Proapoptotic BAX and BAK control multiple initiator caspases
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Inhibition of Bax channel-forming activity by Bcl-2
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
    determination method or standard
    IBA
    Commons category
    Bcl-2
    0 references

    Identifiers

    HGNC ID
    990
    0 references
    PDB structure ID
    WikiProjectMed ID
    Bcl-2
    0 references
     
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