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epidermal growth factor receptor (Q424401)

From Wikidata
mammalian protein found in Homo sapiens
  • erb-b2 receptor tyrosine kinase 1
  • cell proliferation-inducing protein 61
  • receptor tyrosine-protein kinase erbB-1
  • epidermal growth factor receptor tyrosine kinase domain
  • EGFR
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
  • proto-oncogene c-ErbB-1
  • cell growth inhibiting protein 40
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    English
    epidermal growth factor receptor
    mammalian protein found in Homo sapiens
    • erb-b2 receptor tyrosine kinase 1
    • cell proliferation-inducing protein 61
    • receptor tyrosine-protein kinase erbB-1
    • epidermal growth factor receptor tyrosine kinase domain
    • EGFR
    • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
    • proto-oncogene c-ErbB-1
    • cell growth inhibiting protein 40

    Statements

    part of
    molecular function
    identical protein binding
    determination method or standard
    IPI
    18 references
    retrieved
    1 January 2018
    stated in
    EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Parallel visualization of multiple protein complexes in individual cells in tumor tissue
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A Proximity Ligation Assay Using Transiently Transfected, Epitope-Tagged Proteins: Application for in Situ Detection of Dimerized Receptor Tyrosine Kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Conformational coupling across the plasma membrane in activation of the EGF receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Comparative analysis of fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    protein tyrosine kinase activity
    determination method or standard
    IEA
    IMP
    TAS
    IDA
    EXP
    10 references
    retrieved
    1 January 2018
    stated in
    The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Tyrosine phosphorylation controls PCNA function through protein stability
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    EXP
    epidermal growth factor-activated receptor activity
    determination method or standard
    IDA
    IEA
    IMP
    NAS
    6 references
    retrieved
    31 October 2017
    stated in
    Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    NAS
    retrieved
    31 October 2017
    stated in
    ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    NAS
    retrieved
    31 October 2017
    stated in
    Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IMP
    retrieved
    31 October 2017
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    31 October 2017
    stated in
    Tyrosine phosphorylation controls PCNA function through protein stability
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    31 October 2017
    stated in
    Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IPI
    131 references
    retrieved
    1 January 2018
    stated in
    The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
    GOA
    curator
    WormBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Epidermal Growth Factor Receptor (EGFR) Signaling Requires a Specific Endoplasmic Reticulum Thioredoxin for the Post-translational Control of Receptor Presentation to the Cell Surface
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tyrosine phosphorylation controls PCNA function through protein stability
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Substrate specificity of the protein tyrosine phosphatases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Parallel visualization of multiple protein complexes in individual cells in tumor tissue
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGFR/Met association regulates EGFR TKI resistance in breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Survival of cancer cells is maintained by EGFR independent of its kinase activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Epidermal growth factor directs sex-specific steroid signaling through Src activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of amino acids in the N-terminal SH2 domain of phospholipase C gamma 1 important in the interaction with epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Subsets of epidermal growth factor receptors during activation and endocytosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Weak binding to E3 ubiquitin ligase c‐Cbl increases EGFRvA protein stability
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Epidermal Growth Factor Receptor Potentiates MCM7-Mediated DNA Replication through Tyrosine Phosphorylation of Lyn Kinase in Human Cancers
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A novel proteomic screen for peptide-protein interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Threshold-controlled ubiquitination of the EGFR directs receptor fate
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of 14-3-3zeta as an EGF receptor interacting protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A kinase-independent role for EGF receptor in autophagy initiation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A quantitative protein interaction network for the ErbB receptors using protein microarrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Endogenous calmodulin interacts with the epidermal growth factor receptor in living cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Protein Phosphorylation Profiling Using an In Situ Proximity Ligation Assay: Phosphorylation of AURKA-Elicited EGFR-Thr654 and EGFR-Ser1046 in Lung Cancer Cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Determinants of substrate recognition in the protein-tyrosine phosphatase, PTP1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Ligand-induced structural transitions in ErbB receptor extracellular domains
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Mycoplasma Hyorhinis Infection Promotes NF-κB–Dependent Migration of Gastric Cancer Cells
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IPI
    epidermal growth factor-activated receptor activity
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    NAS
    7 references
    retrieved
    1 January 2018
    stated in
    Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    NAS
    retrieved
    1 January 2018
    stated in
    ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    NAS
    retrieved
    1 January 2018
    stated in
    Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Tyrosine phosphorylation controls PCNA function through protein stability
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IBA
    protein tyrosine kinase activity
    determination method or standard
    IDA
    IEA
    IMP
    TAS
    9 references
    retrieved
    1 January 2018
    stated in
    The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Tyrosine phosphorylation controls PCNA function through protein stability
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    cell component
    endosome
    determination method or standard
    IDA
    IEA
    6 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    plasma membrane
    determination method or standard
    IDA
    TAS
    IEA
    7 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane
    GOA
    curator
    UniProt
    UniProt protein ID
    P00533
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Human Protein Atlas
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
    determination method or standard
    IDA
    biological process
    physically interacts with
    Commons category
    Epidermal growth factor receptor
    0 references

    Identifiers

    MeSH descriptor ID
    C512478
    subject named as
    EGFR protein, human
    0 references
    UniProt protein ID
    P00533
    0 references
    Ensembl protein ID
    ENSP00000275493
    0 references
    ENSP00000342376
    0 references
    ENSP00000345973
    0 references
    ENSP00000413843
    0 references
    ENSP00000395243
    0 references
    ENSP00000413354
    0 references
    ENSP00000415559
    0 references
    ENSP00000492462
    0 references
    PDB structure ID
     
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q424401&oldid=2442854697"