insulin receptor (Q422579)

Protein kinase-like domain superfamily

1 reference

tyrosine-protein kinase, insulin-like receptor

1 reference

Fibronectin type III superfamily

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Receptor L-domain superfamily

1 reference

Fibronectin type III, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Receptor L-domain, protein family

1 reference

Furin-like cysteine-rich domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, receptor class II, conserved site, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Furin-like repeat, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

insulin-like growth factor II binding

1 reference

8 April 2019

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

ATP binding

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

insulin-like growth factor receptor binding

1 reference

8 April 2019

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

insulin receptor substrate binding

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

4 references

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

23 May 2017

Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

23 May 2017

Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

23 May 2017

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

protein binding

36 references

8 April 2019

Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

A fluorescent indicator for tyrosine phosphorylation-based insulin signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

An enzyme-linked immunosorbent assay to measure insulin receptor dephosphorylation by PTP1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

The association of phosphoinositide 3‐kinase enhancer A with hepatic insulin receptor enhances its kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Regulation of protein tyrosine phosphatase 1B by sumoylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Comparative analysis of the signaling capabilities of the insulin receptor-related receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

protein tyrosine kinase activity

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

8 April 2019

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

insulin-like growth factor I binding

1 reference

8 April 2019

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

GTP binding

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

PTB domain binding

1 reference

8 April 2019

Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

phosphatidylinositol 3-kinase binding

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

insulin binding

protein domain specific binding

1 reference

8 April 2019

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

amyloid-beta binding

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

transmembrane receptor protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

insulin-activated receptor activity

Ligand-binding properties of the two isoforms of the human insulin receptor

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Insulin receptor: evidence that it is a protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

cargo receptor activity

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

insulin receptor substrate binding

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

protein-containing complex binding

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

insulin receptor complex

1 reference

23 May 2017

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

extracellular exosome

1 reference

23 May 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

receptor complex

1 reference

23 May 2017

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Insulin receptor: evidence that it is a protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

IC

endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

integral component of plasma membrane

1 reference

23 May 2017

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

intracellular anatomical structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06213&geneProductId=UniProtKB:P06213

1 reference

1 January 2018

nuclear envelope

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

integral component of plasma membrane

insulin receptor complex

external side of plasma membrane

2 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

axon

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

nuclear lumen

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

dendrite membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

neuronal cell body membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

extracellular exosome

HDA

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of glucose import

HDA

biological process

NAS

insulin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

5 references

23 May 2017

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

23 May 2017

Ligand-binding properties of the two isoforms of the human insulin receptor

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

23 May 2017

Insulin receptor: evidence that it is a protein kinase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

23 May 2017

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

positive regulation of protein phosphorylation

1 reference

8 April 2019

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

regulation of embryonic development

1 reference

8 April 2019

Homozygous deletion of the human insulin receptor gene results in leprechaunism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of developmental growth

1 reference

8 April 2019

Homozygous deletion of the human insulin receptor gene results in leprechaunism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

1 reference

23 May 2017

regulation of female gonad development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

animal organ morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

transformation of host cell by virus

1 reference

8 April 2019

The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of meiotic cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of protein kinase B signaling

1 reference

23 May 2017

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

regulation of transcription, DNA-templated

1 reference

8 April 2019

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

1 reference

23 May 2017

male sex determination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

epidermis development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

cellular response to insulin stimulus

1 reference

8 April 2019

Ligand-binding properties of the two isoforms of the human insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

protein autophosphorylation

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

8 April 2019

Insulin receptor: evidence that it is a protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of respiratory burst

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of MAPK cascade

exocrine pancreas development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

male gonad development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

carbohydrate metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

positive regulation of DNA replication

1 reference

23 May 2017

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

peptidyl-tyrosine autophosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

activation of protein kinase B activity

1 reference

8 April 2019

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of cell migration

1 reference

8 April 2019

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

cellular response to growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

heart morphogenesis

1 reference

8 April 2019

Homozygous deletion of the human insulin receptor gene results in leprechaunism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

adrenal gland development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of cell population proliferation

IC

positive regulation of glycolytic process

1 reference

8 April 2019

Homozygous deletion of the human insulin receptor gene results in leprechaunism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

activation of protein kinase activity

1 reference

8 April 2019

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

signal transduction

1 reference

23 May 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

glucose homeostasis

1 reference

23 May 2017

Homozygous deletion of the human insulin receptor gene results in leprechaunism

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

protein heterotetramerization

1 reference

8 April 2019

The native alpha 2 beta 2 tetramer is the only subunit structure of the insulin receptor in intact cells and purified receptor preparations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

intracellular signal transduction

1 reference

23 May 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213

receptor-mediated endocytosis

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

learning

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

memory

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of cell population proliferation

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

insulin receptor signaling pathway

IC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

6 references

8 April 2019

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Ligand-binding properties of the two isoforms of the human insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Insulin receptor: evidence that it is a protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of protein-containing complex disassembly

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of MAPK cascade

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

anatomical structure development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

positive regulation of protein kinase B signaling

dendritic spine maintenance

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

amyloid-beta clearance

1 reference

8 April 2019

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

neuron projection maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213

1 reference

8 April 2019

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7397

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

7741

English

object of statement has role

17 August 2016

NPH insulin

agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2108964

bms-754807

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL575448

Gene Atlas image

PBB GE INSR 213792 s at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P06213

1 reference

tyrosine-protein kinase, active site

Identifiers.org

has part(s)

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Furin-like cysteine-rich domain

1 reference

Furin-like repeat

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

protein kinase, ATP binding site

1 reference

tyrosine-protein kinase, receptor class II, conserved site

1 reference

fibronectin type III

1 reference

protein kinase domain

1 reference

Receptor L-domain

1 reference

National Library of Israel J9U ID

Commons category

Insulin receptor

0 references

Identifiers

987007553252205171

1 reference

National Library of Israel Names and Subjects Authority File

NL CR AUT ID

ph121176

subject named as

inzulinové receptory

0 references

MeSH descriptor ID

D011972

subject named as

Receptor, Insulin

0 references

MeSH tree code

D08.811.913.696.620.682.725.400.200

receptor tyrosine kinase

0 references

D12.776.543.750.630.484

D12.776.543.750.750.580.300

receptor tyrosine kinase

0 references

pancreatic hormone receptors

0 references

D12.776.476.568.400.200

Microsoft Academic ID (discontinued)

receptor tyrosine kinase

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

28 October 2013

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016