Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer. (Q41789322)

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scientific article published on 19 November 2012

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English	Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer.	scientific article published on 19 November 2012

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scholarly article

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18 February 2020

Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer (English)

1 reference

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18 February 2020

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Robert C Baxter

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18 February 2020

Timothy E Adams

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18 February 2020

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Sameer A Greenall

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18 February 2020

John D Bentley

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18 February 2020

Lesley A Pearce

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18 February 2020

Judith A Scoble

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18 February 2020

Lindsay G Sparrow

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18 February 2020

Nicola A Bartone

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18 February 2020

Xiaowen Xiao

7

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18 February 2020

Leah J Cosgrove

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18 February 2020

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19 November 2012

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18 February 2020

Journal of Biological Chemistry

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18 February 2020

288

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18 February 2020

59-68

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18 February 2020

1

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18 February 2020

Cushing's syndrome and big IGF-II associated hypoglycaemia in a patient with adrenocortical carcinoma

1 reference

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6 June 2018

Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation

1 reference

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6 June 2018

Minireview: IGF, Insulin, and Cancer

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6 June 2018

Plasma distribution and signaling activities of IGF-II precursors.

1 reference

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6 June 2018

A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo

1 reference

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6 June 2018

Silencing of the insulin receptor isoform A favors formation of type 1 insulin-like growth factor receptor (IGF-IR) homodimers and enhances ligand-induced IGF-IR activation and viability of human colon carcinoma cells.

1 reference

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6 June 2018

Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells

1 reference

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6 June 2018

Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma.

1 reference

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6 June 2018

IGF2: epigenetic regulation and role in development and disease

1 reference

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6 June 2018

Structure and functional analysis of the IGF-II/IGF2R interaction

1 reference

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6 June 2018

The role of insulin-like growth factor binding proteins.

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6 June 2018

Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain

1 reference

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6 June 2018

Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability

1 reference

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6 June 2018

Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.

1 reference

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6 June 2018

Cellular actions of the insulin-like growth factor binding proteins

1 reference

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6 June 2018

Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6

1 reference

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6 June 2018

Post-translational processing of the insulin-like growth factor-2 precursor. Analysis of O-glycosylation and endoproteolysis

1 reference

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6 June 2018

Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3

1 reference

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6 June 2018

Crystallization of the first three domains of the human insulin-like growth factor-1 receptor

1 reference

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6 June 2018

Biophysical and biological properties of naturally occurring high molecular weight insulin-like growth factor II variants.

1 reference

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6 June 2018

Characterization of O-glycosylated precursors of insulin-like growth factor II by matrix-assisted laser desorption/ionization mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537057

6 June 2018

Serum "big insulin-like growth factor II" from patients with tumor hypoglycemia lacks normal E-domain O-linked glycosylation, a possible determinant of normal propeptide processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537057

6 June 2018

Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts

1 reference

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6 June 2018

A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity

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6 June 2018

Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography

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6 June 2018

Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?

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6 June 2018

Parental imprinting of the mouse insulin-like growth factor II gene.

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16 June 2018

Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia

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18 August 2018

Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding.

1 reference

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18 August 2018

Serum high molecular weight form of insulin-like growth factor II from patients with non-islet cell tumor hypoglycemia is O-glycosylated.

1 reference

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18 August 2018

Relaxation of imprinted genes in human cancer.

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18 August 2018

Mature IGF-II prevents the formation of “big” IGF-II/IGFBP-2 complex in the human circulation

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12 December 2020

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Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia

1 reference

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12 December 2020

based on heuristic

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Secretion of noncomplexed 'Big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines

1 reference

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12 December 2020

based on heuristic

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Purification and properties of insulin receptor ectodomain from large-scale mammalian cell culture

1 reference

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12 December 2020

based on heuristic

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Hypoglycaemia associated with the production of insulin-like growth factor II and insulin-like growth factor binding protein 6 by a haemangiopericytoma

1 reference

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12 December 2020

based on heuristic

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Identifiers

10.1074/JBC.M112.432013

1 reference

Europe PubMed Central

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18 February 2020

1 reference

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18 February 2020

1 reference

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18 February 2020

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