Age-associated alterations of the mitochondrial genome (Q41428595)

30 September 2017

title

Age-associated alterations of the mitochondrial genome (English)

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30 September 2017

2

Weindruch R

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30 September 2017

Lee CM

1

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30 September 2017

Aiken JM

series ordinal

3

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30 September 2017

publication date

1 January 1997

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Free Radical Biology and Medicine

30 September 2017

language of work or name

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30 September 2017

volume

22

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30 September 2017

issue

7

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30 September 2017

page(s)

1259-1269

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publication type of scholarly work

30 September 2017

review article

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Hydroperoxide metabolism in mammalian organs

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Aging: a theory based on free radical and radiation chemistry

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Mitochondrial role in cell aging

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A mitochondrial membrane hypothesis of aging

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7 January 2021

Is cell aging caused by respiration-dependent injury to the mitochondrial genome?

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7 January 2021

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases

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7 January 2021

Sequence and organization of the human mitochondrial genome

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7 January 2021

The elucidation of the human mitochondrial genome: a historical perspective

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7 January 2021

Replication of animal mitochondrial DNA.

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7 January 2021

The mitochondrial genome--breaking the magic circle

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7 January 2021

Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells

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7 January 2021

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration

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7 January 2021

Late-onset mitochondrial myopathy

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7 January 2021

Ragged red fibers in normal aging and inflammatory myopathy

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7 January 2021

Respiratory chain failure in adult muscle fibres: relationship with ageing and possible implications for the neuronal pool

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing--a cytochemical-immunohistochemical study

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Age-dependent impairment of mitochondrial function in primate brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Age-associated damage in mitochondrial function in rat hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Decline with age of the respiratory chain activity in human skeletal muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Effect of age on oxidative phosphorylation in the rat.

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Age-linked changes in the activity of enzymes of the tricarboxylate cycle and lipid oxidation, and of carnitine content, in muscles of the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

The Ageing of Skeletal (Striated) Muscle by Changes of Recovery Metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Comparison between developmental and senescent changes in enzyme activities linked to energy metabolism in rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Oxidative damage to DNA in mammalian chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

DNA oxidative damage and life expectancy in houseflies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Protection of DNA damage by dietary restriction

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

A lifetime of retinal light exposure does not appear to increase mitochondrial mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Diseases of the mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Mitochondrial encephalomyopathies: clinical and molecular analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Ageing-associated 5 kb deletion in human liver mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Deleterious mitochondrial DNA mutations accumulate in aging human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Rapid accumulation of deleted mitochondrial deoxyribonucleic acid in postmenopausal ovaries

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Human ovarian aging and mitochondrial DNA deletion

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Age-associated damage in mitochondrial DNA in human hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Multiple mitochondrial DNA deletions in an elderly human individual

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Aging-associated deletions of human diaphragmatic mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Accumulation of deletions in MtDNA during tissue aging: analysis by long PCR

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Direct repeat sequences are not required at the breakpoints of age-associated mitochondrial DNA deletions in rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Multiple deletions in mitochondrial DNA are present in senescent mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Multiple deletions are detectable in mitochondrial DNA of aging mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Multiple, large deletions in rat mitochondrial DNA: evidence for a major hot spot

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Rearrangements in the shorter arc of rat mitochondrial DNA involving the region of the heavy and light strand promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Detection of deletions in the mitochondrial genome of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Cardiomyopathy with mitochondrial DNA mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Different mechanisms inferred from sequences of human mitochondrial DNA deletions in ocular myopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Significant existence of deleted mitochondrial DNA in cirrhotic liver surrounding hepatic tumor

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Pearson's marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

A topoisomerase II cleavage site is associated with a novel mitochondrial DNA deletion

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Comparison of different quantitative PCR procedures in the analysis of the 4977-bp deletion in human mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Fragmentation of human heart mitochondrial DNA associated with premature aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Overfeeding and life span in Tokophrya infusionum

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

EFFECT OF DELAYED AND RESUMED GROWTH ON THE LONGEVITY OF A FISH (LEBISTES RETICULATUS, PETERS) IN CAPTIVITY.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Food restriction in rodents: an evaluation of its role in the study of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Caloric restriction and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Oxidative stress, caloric restriction, and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Mitochondrial aging and lipoperoxidative products

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900546-1

7 January 2021

10.1016/S0891-5849(96)00546-1

Identifiers

DOI

1 reference

30 September 2017

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