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CD4 molecule (Q412587)

From Wikidata
mammalian protein found in Homo sapiens
  • CD4 Antigens
  • T-cell surface antigen T4/Leu-3
  • CD4 receptor
  • CD4 antigen (p55)
  • T-cell surface glycoprotein CD4
  • CD4
  • CD4 protein
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    English
    CD4 molecule
    mammalian protein found in Homo sapiens
    • CD4 Antigens
    • T-cell surface antigen T4/Leu-3
    • CD4 receptor
    • CD4 antigen (p55)
    • T-cell surface glycoprotein CD4
    • CD4
    • CD4 protein

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    15 references
    retrieved
    8 April 2019
    stated in
    The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Energetics of the HIV gp120-CD4 binding reaction
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cloning of ACP33 as a novel intracellular ligand of CD4
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Dimeric association and segmental variability in the structure of human CD4
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural definition of a conserved neutralization epitope on HIV-1 gp120
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    MHC class II protein binding
    determination method or standard
    IBA
    IDA
    IPI
    NAS
    5 references
    retrieved
    8 April 2019
    stated in
    Role of CD4 and CD8 in T cell activation and differentiation
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    CD4 Ligation on Human Blood Monocytes Triggers Macrophage Differentiation and Enhances HIV Infection
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between CD4 and class II MHC molecules mediates cell adhesion
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IBA
    cell component
    plasma membrane
    determination method or standard
    IDA
    TAS
    IEA
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Interaction between CD4 and class II MHC molecules mediates cell adhesion
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P01730
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
    determination method or standard
    IDA
    biological process
    Gene Atlas image
    PBB GE CD4 203547 at fs.png
    732 × 530; 11 KB
    0 references
    Commons category
    CD4
    0 references

    Identifiers

    PDB structure ID
     
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