Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates (Q41049000)

26 September 2017

title

Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates (English)

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26 September 2017

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Singh H

1

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26 September 2017

publication date

1 April 1996

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Current Opinion in Immunology

26 September 2017

published in

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26 September 2017

volume

8

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26 September 2017

issue

2

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26 September 2017

page(s)

160-165

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publication type of scholarly work

26 September 2017

review article

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Molecular and cellular origins of B lymphocyte diversity

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The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

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The PU.1 transcription factor is the product of the putative oncogene Spi-1

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Spi-1 is a putative oncogene in virally induced murine erythroleukaemias

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Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins

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PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity

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PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer

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An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene

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BLyF, a novel cell-type- and stage-specific regulator of the B-lymphocyte gene mb-1

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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages

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Bipotential precursors of B cells and macrophages in murine fetal liver

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The Ikaros gene is required for the development of all lymphoid lineages

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Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment

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A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

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Structure and function of helix-loop-helix proteins

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Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

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E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

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The helix-loop-helix gene E2A is required for B cell formation

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Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

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Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression

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Failure of B-cell differentiation in mice lacking the transcription factor EBF.

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A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation

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Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis

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The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

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A pre-B- and B cell-specific DNA-binding protein, EBB-1, which binds to the promoter of the VpreB1 gene.

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

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Transcriptional control points during lymphopoiesis

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A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

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RAG-1-deficient mice have no mature B and T lymphocytes

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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7 January 2021

10.1016/S0952-7915(96)80053-7

Identifiers

DOI

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26 September 2017

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