lactotransferrin (Q410246)

http://www.ebi.ac.uk/interpro/protein/P02788

Transferrin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transferrin family, iron binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Lactoferrin.png
640 × 480; 175 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

protein serine/threonine kinase activator activity

1 reference

8 April 2019

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

protein binding

8 references

8 April 2019

Characterization of an eppin protein complex from human semen and spermatozoa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Interactions of surface-displayed glycolytic enzymes of Mycoplasma pneumoniae with components of the human extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Hepatitis C virus envelope proteins bind lactoferrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Interaction of calmodulin with lactoferrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Interactions of surface-displayed glycolytic enzymes of Mycoplasma pneumoniae with components of the human extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

serine-type peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

lipopolysaccharide binding

Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide

2 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

26 September 2017

Structure-Function Relationship of Antibacterial Synthetic Peptides Homologous to a Helical Surface Region on Human Lactoferrin against Escherichia coli Serotype O111

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

cysteine-type endopeptidase inhibitor activity

1 reference

8 April 2019

New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

lipopolysaccharide binding

1 reference

8 April 2019

Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

cell component

cytoplasm

The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Ensembl genome database project

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

secretory granule

1 reference

8 April 2019

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

extracellular region

cell surface

1 reference

8 April 2019

Characterization of an eppin protein complex from human semen and spermatozoa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

specific granule

1 reference

8 April 2019

Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

phagocytic vesicle lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

extracellular exosome

3 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

26 September 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

7 references

26 September 2017

26 September 2017

Characterization of an eppin protein complex from human semen and spermatozoa

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

26 September 2017

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

26 September 2017

The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

26 September 2017

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

26 September 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

26 September 2017

New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

specific granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

tertiary granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

7 references

8 April 2019

8 April 2019

Characterization of an eppin protein complex from human semen and spermatozoa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

protein-containing complex

1 reference

8 April 2019

Characterization of an eppin protein complex from human semen and spermatozoa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

extracellular exosome

positive regulation of osteoblast proliferation

biological process

1 reference

8 April 2019

Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

1 reference

26 September 2017

positive regulation of chondrocyte proliferation

1 reference

8 April 2019

Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

negative regulation of osteoclast development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

ossification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

regulation of tumor necrosis factor production

1 reference

8 April 2019

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

negative regulation of viral process

1 reference

8 April 2019

The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

negative regulation of ATP-dependent activity

1 reference

8 April 2019

The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

antibacterial humoral response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

3 references

8 April 2019

8 April 2019

Identification of the bactericidal domain of lactoferrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

8 April 2019

The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

bone morphogenesis

1 reference

8 April 2019

Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

iron ion homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

positive regulation of bone mineralization involved in bone maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

negative regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

ion transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

1 reference

26 September 2017

proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

positive regulation of protein serine/threonine kinase activity

1 reference

8 April 2019

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

negative regulation of single-species biofilm formation in or on host organism

1 reference

8 April 2019

A component of innate immunity prevents bacterial biofilm development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

negative regulation by host of viral process

1 reference

8 April 2019

Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

negative regulation of lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

negative regulation of tumor necrosis factor (ligand) superfamily member 11 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

retina homeostasis

IEP

1 reference

26 September 2017

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

negative regulation of viral genome replication

IEP

1 reference

8 April 2019

The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

innate immune response in mucosa

1 reference

8 April 2019

A component of innate immunity prevents bacterial biofilm development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

positive regulation of osteoblast differentiation

1 reference

8 April 2019

Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

humoral immune response

1 reference

8 April 2019

Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

defense response to bacterium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

positive regulation of toll-like receptor 4 signaling pathway

1 reference

8 April 2019

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

siderophore-dependent iron import into cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

antimicrobial humoral response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

innate immune response

1 reference

26 September 2017

Structure-Function Relationship of Antibacterial Synthetic Peptides Homologous to a Helical Surface Region on Human Lactoferrin against Escherichia coli Serotype O111

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

negative regulation of membrane potential

1 reference

26 September 2017

Structure-Function Relationship of Antibacterial Synthetic Peptides Homologous to a Helical Surface Region on Human Lactoferrin against Escherichia coli Serotype O111

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

antimicrobial humoral immune response mediated by antimicrobial peptide

1 reference

8 April 2019

Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

negative regulation of cysteine-type endopeptidase activity

1 reference

8 April 2019

New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02788&geneProductId=UniProtKB:P02788

1 reference

26 September 2017

antifungal humoral response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

1 reference

8 April 2019

retina homeostasis

HEP

1 reference

8 April 2019

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02788

http://purl.uniprot.org/uniprot/P02788

HEP

exact match

1 reference

Transferrin family, iron binding site

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02788

Transferrin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02788

Commons category

Lactoferrin

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Identifiers

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1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID (discontinued)

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4 August 2016

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4 August 2016

1 reference

4 August 2016

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4 August 2016

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4 August 2016

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4 August 2016

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4 August 2016

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4 August 2016

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4 August 2016