Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis (Q40935748)

25 September 2017

title

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis (English)

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25 September 2017

Sabbatini P

1

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25 September 2017

McCormick F

series ordinal

2

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25 September 2017

publication date

1 August 1999

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Journal of Biological Chemistry

25 September 2017

language of work or name

English

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published in

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25 September 2017

volume

274

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25 September 2017

issue

34

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25 September 2017

page(s)

24263-24269

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Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

25 September 2017

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

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Phosphoinositide 3-kinases: A conserved family of signal transducers

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Signalling through the lipid products of phosphoinositide-3-OH kinase

21 January 2018

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

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Dimerization of cell surface receptors in signal transduction

21 January 2018

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Interleukin 3-dependent survival by the Akt protein kinase

21 January 2018

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Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

21 January 2018

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

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Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

21 January 2018

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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Cancer. p53, guardian of the genome

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Cell cycle control and cancer

21 January 2018

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Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

21 January 2018

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Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways

21 January 2018

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Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest

21 January 2018

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Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

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The polyproline region of p53 is required to activate apoptosis but not growth arrest.

21 January 2018

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Bcl-2 blocks p53-dependent apoptosis

21 January 2018

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

21 January 2018

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Cell death: the significance of apoptosis

21 January 2018

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The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

21 January 2018

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

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21 January 2018

Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Lamin proteolysis facilitates nuclear events during apoptosis

21 January 2018

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ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis

21 January 2018

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21 January 2018

Caspases: Enemies Within

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Oncogene-dependent apoptosis is mediated by caspase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition

21 January 2018

1 reference

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

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Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation

21 January 2018

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

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Thymocyte apoptosis induced by p53-dependent and independent pathways

21 January 2018

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p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

ralGDS family members interact with the effector loop of ras p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Selective extraction of polyoma DNA from infected mouse cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Caspases: the proteases of the apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

Role of p53 in apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.34.24263

21 January 2018

Identifiers

DOI

10.1074/JBC.274.34.24263

1 reference

25 September 2017

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