Cytochromes P450: their active-site structure and mechanism of oxidation (Q40861918)

24 September 2017

title

Cytochromes P450: their active-site structure and mechanism of oxidation (English)

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24 September 2017

Koymans L

1

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24 September 2017

Donné-op den Kelder GM

series ordinal

2

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24 September 2017

Koppele Te JM

series ordinal

3

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24 September 2017

Vermeulen NP

series ordinal

4

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24 September 2017

publication date

1 January 1993

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24 September 2017

language of work or name

English

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published in

Drug Metabolism Reviews

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24 September 2017

volume

25

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24 September 2017

issue

3

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24 September 2017

page(s)

325-387

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publication type of scholarly work

24 September 2017

review article

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P450 genes: structure, evolution, and regulation

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21 January 2018

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The involvement of free radicals in the mechanisms of monooxygenases

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High-resolution crystal structure of cytochrome P450cam

21 January 2018

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Crystal structure of substrate-free Pseudomonas putida cytochrome P-450

21 January 2018

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A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase

21 January 2018

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Coupling of spin, substrate, and redox equilibriums in cytochrome P450

21 January 2018

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Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure

21 January 2018

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Crystal structure of the carbon monoxide-substrate-cytochrome P-450CAM ternary complex

21 January 2018

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Tyrosine-96 as a natural spectroscopic probe of the cytochrome P-450cam active site

21 January 2018

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Bio-organic chemistry and cytochrome P-450-dependent catalysis

21 January 2018

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The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM

21 January 2018

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Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation

21 January 2018

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Proton coupling in the cytochrome P-450 spin and redox equilibriums

21 January 2018

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Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam

21 January 2018

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Formation, crystal structure, and rearrangement of a cytochrome P-450cam iron-phenyl complex

21 January 2018

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Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation

21 January 2018

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Secondary structure prediction of 52 membrane-bound cytochromes P450 shows a strong structural similarity to P450cam

21 January 2018

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Proteins from eight eukaryotic cytochrome P-450 families share a segmented region of sequence similarity

21 January 2018

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Site-directed mutageneses of rat liver cytochrome P-450d: axial ligand and heme incorporation

21 January 2018

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A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin

21 January 2018

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Structure-function relationships of cytochrome P-450 laurate (omega-1)-hydroxylase

21 January 2018

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Secondary structure and membrane topology of cytochrome P450s

21 January 2018

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Microsomal cytochrome P-450: substrate binding, membrane interactions, and topology

21 January 2018

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Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies

21 January 2018

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Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane

21 January 2018

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Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptide

21 January 2018

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Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex

21 January 2018

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Protein-protein interactions in microsomal cytochrome P-450 isozyme LM2 and their effect on substrate binding

21 January 2018

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Electron spin resonance studies of wild-type and mutant cytochromes P-450d: effects of mutations at proximal, aromatic and distal sites on g values

21 January 2018

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Cytochrome P-450: cytochrome P-450 reductase interactions

21 January 2018

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Selective chemical modification of cytochrome P-450SCC lysine residues. Identification of lysines involved in the interaction with adrenodoxin

21 January 2018

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Nanosecond fluorometry of the single tryptophan in cytochrome P-450e (P450IIB2).

21 January 2018

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cDNA cloning and functional expression in yeast Saccharomyces cerevisiae of beta-naphthoflavone-induced rabbit liver P-450 LM4 and LM6.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539308993979

Protein engineering by cDNA recombination in yeasts: shuffling of mammalian cytochrome P-450 functions

21 January 2018

1 reference

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Sequence requirements for cytochromes P450IIA1 and P450IIA2 catalytic activity: evidence for both specific and non-specific substrate binding interactions through use of chimeric cDNAs and cDNA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

A single amino acid substitution converts cytochrome P450(14DM) to an inactive form, cytochrome P450SG1: complete primary structures deduced from cloned DNAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Molecular cloning and sequence analysis of cDNA encoding rat adrenal cytochrome P-450(11)beta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Homologous sequences in steroidogenic enzymes, steroid receptors and a steroid binding protein suggest a consensus steroid-binding sequence

21 January 2018

1 reference

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Hybrid cytochromes P-450 identify a substrate binding domain in P-450IIC5 and P-450IIC4.

21 January 2018

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A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.

21 January 2018

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The cytochromes P-448--a unique family of enzymes involved in chemical toxicity and carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539308993979

Metabolic activation of carcinogens and toxic chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Stereoselectivity of cytochrome P-450 isozymes and epoxide hydrolase in the metabolism of polycyclic aromatic hydrocarbons

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539308993979

Highly purified cytochrome P-448 and P-450 from rat liver microsomes

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539308993979

Metabolism of 2-acetylaminofluorene by eight different forms of cytochrome P-450 isolated from rat liver

21 January 2018

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Cytochrome P-450 inactivation: structure of the prosthetic heme adduct with propyne

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

N-Methylprotoporphyrin IX: chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Active site model of cytochrome P-450 LM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Polymorphic hydroxylation of Debrisoquine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

A molecular model for the enzyme cytochrome P450(17 alpha), a major target for the chemotherapy of prostatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Analysis, design and modification of loop regions in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Structural determinants of the conformations of medium-sized loops in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Solvation of the active site of cytochrome P450-cam

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

The active site of cytochrome P-450 nifedipine oxidase: a model-building study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993979

10.3109/03602539308993979

21 January 2018

Identifiers

DOI

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24 September 2017

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