apolipoprotein C3 (Q4068038)

http://www.ebi.ac.uk/interpro/protein/P02656

Apolipoprotein CIII superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02656

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

lipase inhibitor activity

4 references

17 October 2017

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

17 October 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

17 October 2017

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

17 October 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

enzyme regulator activity

1 reference

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

high-density lipoprotein particle receptor binding

1 reference

17 October 2017

Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

1 reference

8 April 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

3 references

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Behavior of human apolipoprotein E in aqueous solutions and at interfaces

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

lipase inhibitor activity

5 references

8 April 2019

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

high-density lipoprotein particle receptor binding

very-low-density lipoprotein particle

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

17 October 2017

Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

17 October 2017

Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

17 October 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

spherical high-density lipoprotein particle

1 reference

17 October 2017

Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

extracellular exosome

intermediate-density lipoprotein particle

1 reference

17 October 2017

Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

1 reference

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

very-low-density lipoprotein particle

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Identification of disulfide-linked apolipoprotein species in human lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of cholesterol import

HDA

biological process

1 reference

8 April 2019

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of very-low-density lipoprotein particle remodeling

IC

chylomicron remnant clearance

1 reference

8 April 2019

Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of fatty acid biosynthetic process

regulation of Cdc42 protein signal transduction

1 reference

8 April 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of high-density lipoprotein particle clearance

1 reference

17 October 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

1 reference

8 April 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of low-density lipoprotein particle clearance

1 reference

17 October 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

negative regulation of very-low-density lipoprotein particle clearance

1 reference

17 October 2017

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

retinoid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of receptor-mediated endocytosis

1 reference

8 April 2019

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

lipid catabolic process

1 reference

8 April 2019

negative regulation of lipoprotein lipase activity

3 references

17 October 2017

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

17 October 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

17 October 2017

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia

cholesterol homeostasis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

very-low-density lipoprotein particle assembly

1 reference

8 April 2019

Apolipoprotein C-III: understanding an emerging cardiovascular risk factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process

1 reference

8 April 2019

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of lipid metabolic process

1 reference

8 April 2019

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

reverse cholesterol transport

1 reference

8 April 2019

Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia

IC

triglyceride homeostasis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

triglyceride metabolic process

1 reference

8 April 2019

Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

triglyceride catabolic process

1 reference

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

chylomicron remodeling

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

lipoprotein metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

negative regulation of triglyceride catabolic process

3 references

8 April 2019

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of high-density lipoprotein particle clearance

negative regulation of low-density lipoprotein particle clearance

cholesterol homeostasis

negative regulation of lipoprotein lipase activity

4 references

8 April 2019

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656