The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation (Q40484581)

20 September 2017

The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation (English)

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Human T-lymphotropic virus 1

20 September 2017

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Renaud Mahieux

7

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Maria Elena Bottazzi

9

object named as

Maria Elena Bottazzi

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20 September 2017

10

Fatah Kashanchi

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20 September 2017

Kylene Kehn

1

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20 September 2017

Cynthia de la Fuente

2

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20 September 2017

Katharine Strouss

3

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20 September 2017

Reem Berro

4

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20 September 2017

Hua Jiang

5

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20 September 2017

John Brady

6

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20 September 2017

Anne Pumfery

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20 September 2017

language of work or name

English

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publication date

1 January 2005

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20 September 2017

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20 September 2017

24

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20 September 2017

525-540

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20 September 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208105

20 September 2017

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cites work

The proteasome: structure, function, and role in the cell

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The proteasome: a novel target for cancer chemotherapy

21 January 2018

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Engineered mutants of pRB with improved growth suppression potential.

21 January 2018

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Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Induction of G1 arrest and apoptosis in human jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and elevating p27Kip1, p21Cip1/WAF1, and Bax proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Transgenic mouse models for HTLV-I infection

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Rb function in cell-cycle regulation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Role of E2F in cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Clinical update: proteasome inhibitors in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Direct binding of the N-terminus of HTLV-1 tax oncoprotein to cyclin-dependent kinase 4 is a dominant path to stimulate the kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human T-cell leukemia virus type I and adult T-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Retinoblastoma protein partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Direct coupling of the cell cycle and cell death machinery by E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Expression and phosphorylation status of retinoblastoma protein in adult T-cell leukemia/lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

The Rb/E2F pathway and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

The proteasome in cancer biology and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Overexpression of pRB in human pancreatic carcinoma cells: function in chemotherapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Identification of a growth suppression domain within the retinoblastoma gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

The susceptibility to Fas-induced apoptosis in normal enterocytes is regulated on the level of cIAP1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Regulation of RNA polymerase III transcription during cell cycle entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

HTLV-I Tax is a zinc-binding protein: role of zinc in Tax structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Howard Temin memorial lectureship. Molecular biology of HTLV-1: deregulation of host cell gene expression and cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

A single BIR domain of XIAP sufficient for inhibiting caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human T cell leukemia virus type I (HTLV-I) and human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Both the PPPY and PTAP motifs are involved in human T-cell leukemia virus type 1 particle release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Mechanism of active transcriptional repression by the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Cellular targets for transformation by the adenovirus E1A proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Protein profile of tax-associated complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Multiple viral strategies of HTLV-1 for dysregulation of cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

What is the restriction point?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Transdominant human T-cell lymphotropic virus type I TAX1 mutant that fails to localize to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Stimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208105

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Dimensions Publication ID

20 September 2017

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